Here’s how readers responded to a You Make the Call question about the role of transplant in gamma-delta T-cell lymphoma.
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Yes, once the patient has achieved PET-negative complete remission, perform consolidation therapy with autologous hematopoietic cell transplantation (AHCT).
Farnoush Abar, MD, MPH
Due to the fact that gamma-delta T-cell lymphomas have a very poor prognosis, I would advise an allogeneic hematopoietic cell transplantation (alloHCT) if there is at least a partial response to CHOEP and a suitable donor can be found. Otherwise, I would recommend an AHCT as consolidation treatment after CHOEP.
Stamatis Karakatsanis, MD
Yes. In a young patient with gamma-delta T-cell lymphoma, the only curative approach is alloHCT.
Guillermo Sanz, MD, PhD
Hospital Universitario y
Politécnico de La Fe
I would see what the response is to chemotherapy and decide about a transplant later.
Behrooz Zidehsarai, MD
I would treat with oral methotrexate and assess the response. If the response is suboptimal, I would consider six cycles of CHOEP with or without methotrexate maintenance. I would consider an autograft if the lymphoma relapses and brentuximab vedotin as a part of a salvage regimen.
Mobin Paul, MD, MBBS
No. Consider transplant after initial treatment with targeted therapy.
Aubrey A. Lurie, MD
VA Medical Center
David H. Ross, MD
Cherry Hill, NJ