Multiple Myeloma

A collection of features and news articles published in ASH Clinical News related to multiple myeloma.

European Commission Approves Selinexor Plus Dexamethasone for Relapsed/Refractory Myeloma

Selinexor, in combination with dexamethasone, has been granted conditional marketing authorization by the European Commission (EC) for the treatment of adult patients with multiple...

FDA Approves Isatuximab-irfc Combination for Relapsed/Refractory Myeloma

Isatuximab-irfc, in combination with carfilzomib and dexamethasone (Isa-Kd), was approved by the U.S. Food and Drug Administration (FDA) on March 31, 2021 for the...

FDA Approves Idecabtagene Vicleucel for Relapsed or Refractory Multiple Myeloma

The U.S. Food and Drug Administration (FDA) has approved idecabtagene vicleucel (ide-cel) as the first B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell...

Does Elotuzumab Improve PFS in High-Risk Myeloma?

The addition of the anti-SLAMF7 antibody elotuzumab to lenalidomide, bortezomib, and dexamethasone (RVd) induction and maintenance did not improve outcomes for patients with previously...
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Ixazomib Combination Improves PFS Versus Placebo in Patients With Transplant-Ineligible Myeloma

When researchers added ixazomib to continuous lenalidomide-dexamethasone (Rd) in patients with newly diagnosed, transplant-ineligible multiple myeloma (MM), they observed that the treatment regimen was...

Daratumumab and Hyaluronidase-fihj Approved for Light Chain Amyloidosis

The combination of daratumumab and hyaluronidase-fihj and bortezomib, cyclophosphamide, and dexamethasone (D-VCd) was granted accelerated approval for the treatment of adults with newly diagnosed...

Charting the Myeloma Immunotherapy Landscape

A bevy of forthcoming immunotherapies for multiple myeloma over the next few years raises hopes, as well as questions about combinations, sequencing, and potential...

Examining Outcomes Among Hispanic Patients With Multiple Myeloma

Hispanic and non-Hispanic Black patients with multiple myeloma (MM) more often present with disease at a younger age and with significant renal dysfunction. These...
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Idecabtagene Vicleucel Promising in Pretreated Myeloma

Three-quarters of patients with heavily pretreated multiple myeloma responded to treatment with the B-cell maturation antigen (BCMA)−targeted chimeric antigen receptor (CAR) T-cell therapy idecabtagene...
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Evaluating Iberdomide Plus Daratumumab or Bortezomib in Relapsed/Refractory Myeloma

Triplet combinations consisting of iberdomide, a cereblon E3 ligase immunomodulatory drug, with dexamethasone and daratumumab (IberDd) or bortezomib and dexamethasone (IberVd) demonstrated favorable tolerability...