Multiple Myeloma

A collection of features and news articles published in ASH Clinical News related to multiple myeloma.

Hematologic Malignancies Drive In-Hospital Death Rates

In the past 17 years, the overall rate of in-hospital deaths among patients with hematologic malignancies has decreased by 30 percent, with a corresponding...

FDA Halts Trials of Venetoclax for Myeloma

The U.S. Food and Drug Administration (FDA) has issued a warning to health-care professionals and clinical investigators about the risks associated with the investigational...

FDA’s ODAC Rejects Selinexor for Myeloma

In an 8-to-5 vote, the U.S. Food and Drug Administration's (FDA’s) Oncologic Drug Advisory Committee (ODAC) decided against recommending accelerated approval of selinexor for...

Post-Transplant Ixazomib Maintenance Prolongs Survival in Newly Diagnosed Myeloma

For patients with newly diagnosed multiple myeloma (MM) who relapse following autologous hematopoietic cell transplantation (AHCT), maintenance therapy with the oral proteasome inhibitor (PI)...

First Patients Treated in U.S. CRISPR Study

The University of Pennsylvania has launched a trial of CRISPR-based gene editing in humans, and the first patients have been treated with the powerful...
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Carfilzomib Versus Bortezomib: Comparing Proteasome Inhibitors in Newly Diagnosed Myeloma

Carfilzomib plus melphalan and prednisone (KMP) failed to improve survival outcomes for patients with newly diagnosed multiple myeloma (MM) compared with bortezomib plus melphalan...

How I Treat In Brief: Treating the Young Patient With Multiple Myeloma

Recently, Sara Gandolfi, MD; Claudia Paba Prada, MD; and Paul G. Richardson, MD, discussed the treatment of younger patients with multiple myeloma, balancing disease...

ELOQUENT-3: A New Elotuzumab-Based Triplet Combination in Previously Treated Myeloma

Results from the phase II ELOQUENT-3 trial demonstrate that the combination of elotuzumab plus pomalidomide and dexamethasone extended progression-free survival (PFS) compared with pomalidomide...

Lenalidomide Maintenance Extends Survival Over Observation Alone in Newly Diagnosed Myeloma

New results from the large phase III Myeloma XI trial confirm that maintenance therapy with lenalidomide improves progressionfree survival (PFS) over observation alone in...

BCMA-Targeting Antibody Associated With Clinical Activity in Previously Treated Myeloma

In a first-in-human trial published in Lancet Oncology, the anti–B-cell maturation antigen (BCMA) antibody GSK2857916 was associated with clinical activity and was reasonably well...

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