Bleeding Disorders

A collection of features and news articles published in ASH Clinical News related to bleeding disorders.

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Defining Incidence and Mortality Rates of Intracranial Hemorrhage in Patients With Hemophilia

Compared with the general population, intracranial hemorrhage (ICH) rates are higher in all patients with hemophilia, according to a study published in Blood. Reported...

Patient-Reported Outcome Questionnaire Shows Promise for Monitoring ITP

A draft version of a 10-item patient-reported outcome (PRO) questionnaire has been developed to evaluate the impact of immune thrombocytopenia (ITP) on patients and...

rFIXFc as Prophylaxis and Treatment in Pediatric Hemophilia B

Results from the phase III B-LONG study published in Blood Advances found that recombinant factor IX Fc fusion protein (rFIXFc) was an effective prophylactic...
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Corticosteroid-Dependent or Corticosteroid-Unresponsive Primary ITP

This month, Waleed Ghanima, MD, PhD, Terry Gernsheimer, MD, and David J. Kuter, MD, DPhil, review treatment options for adult patients with primary immune...
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Evaluating Two New Options for Hereditary Hemorrhagic Telangiectasia

At EHA2021 Virtual, researchers shared safety and efficacy findings of two agents for the treatment of the rare disease hereditary hemorrhagic telangiectasia (HHT): pazopanib...

Afibrinogenemia: A Rare, Often Overlooked Bleeding Disorder

Afibrinogenemia is a very rare, inherited blood disorder in which the blood does not clot normally because of a mutation that leads to the...
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Outcomes After ABO-Incompatible Platelet Transfusions in Patients With Intracerebral Hemorrhage

For patients with intracerebral hemorrhage (ICH) who received an acute platelet transfusion within 24 hours of hospital admission, the use of an incompatible platelet...

Characterizing Complications Among Infants and Toddlers With von Willebrand Disease

A new report published in Blood Advances describes the experiences of infants and toddlers living with von Willebrand disease (VWD), highlighting the role and...

Investigation Finds Hemophilia Gene Therapy Likely Did Not Cause Hepatocellular Carcinoma

An investigation found that etranacogene dezaparvovec was unlikely to have caused a case of hepatocellular carcinoma (HCC) in a participant of the HOPE-B trial,...
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International Working Group Publishes Revised Definitions for Remission, Relapse in Immune TTP

The International Working Group (IWG) for thrombotic thrombocytopenic purpura (TTP) has published revised definitions for response, exacerbation, remission, and relapse of immune-mediated TTP (iTTP)...