A collection of features and news articles published in ASH Clinical News related to bleeding disorders.
Outcomes After ABO-Incompatible Platelet Transfusions in Patients With Intracerebral Hemorrhage
For patients with intracerebral hemorrhage (ICH) who received an acute platelet transfusion within 24 hours of hospital admission, the use of an incompatible platelet...
Characterizing Complications Among Infants and Toddlers With von Willebrand Disease
A new report published in Blood Advances describes the experiences of infants and toddlers living with von Willebrand disease (VWD), highlighting the role and...
Investigation Finds Hemophilia Gene Therapy Likely Did Not Cause Hepatocellular Carcinoma
An investigation found that etranacogene dezaparvovec was unlikely to have caused a case of hepatocellular carcinoma (HCC) in a participant of the HOPE-B trial,...
International Working Group Publishes Revised Definitions for Remission, Relapse in Immune TTP
The International Working Group (IWG) for thrombotic thrombocytopenic purpura (TTP) has published revised definitions for response, exacerbation, remission, and relapse of immune-mediated TTP (iTTP)...
TPO-RAs and ITP: Eltrombopag Induces High Efficacy, But Avatrombopag Offers Advantages
A pair of studies presented at the 2020 American Society of Hematology Annual Meeting analyzed the thrombopoietin receptor agonist (TPO-RA) eltrombopag in two settings:...
DDAVP Prevents Post-Intervention Bleeding Complications in Patients With Low von Willebrand Factor Levels
A recent study suggests 1-desamino-8-D-arginine vasopressin (DDAVP) prevents bleeding in patients with low von Willebrand factor (VWF) levels undergoing major and minor elective procedures....
VLX-1005 Receives Orphan Drug Designation
The FDA granted orphan drug designation to VLX-1005 as thrombosis prophylaxis in patients with heparin-induced thrombocytopenia (HIT).
According to its manufacturer, Veralox Therapeutics, preclinical data...
Are Rare Cases of Immune Thrombocytopenia Linked to the COVID Vaccine?
A small number of patients have developed immune thrombocytopenia (ITP) after receiving the Pfizer/BioNTech and Moderna coronavirus vaccines. Whether the onset of the condition...
New HOPE for Hemophilia B: One-Time Gene Therapy Abolishes Bleeding in Most Patients
A single dose of the gene therapy drug etranacogene dezaparvovec increased factor IX (FIX) activity levels, and eliminated the need for prophylactic FIX, in...
Adding Mycophenolate to Corticosteroids Improves Response as Frontline Option in Immune Thrombocytopenia
In results from the randomized, controlled FLIGHT trial, patients with immune thrombocytopenia (ITP) who received mycophenolate mofetil (MMF) plus corticosteroids as first-line therapy were...
