Unlocking Applications for RNA Sequencing
RNA sequencing is a genomics technology that gives scientists a transcriptome-wide view of gene expression and messenger RNA (mRNA) splicing. The tool is already...
Demystifying DNA Variant Reporting
As the understanding of the pathogenesis of hematologic malignancies advances, molecular profiling by next-generation sequencing (NGS) is playing larger role in the diagnosis, prognosis,...
Meet the Munich Leukemia Laboratory: Using Modern Technology to Find Clues to Hematologic Mysteries
At its core, the Munich Leukemia Laboratory (MLL) is like any other diagnostic lab.
“We receive samples and send reports,” one of its three cofounders,...
Demystifying PCR-Based Molecular Monitoring in CML
When imatinib, the first tyrosine kinase inhibitor (TKI), was approved for the treatment of chronic myeloid leukemia (CML) in 2001, the disease’s natural history...
Demystifying Bispecific Antibodies for Hematologic Malignancies
Since the U.S. Food and Drug Administration’s (FDA’s) initial approval of the anti-CD20 antibody rituximab in 1997 to treat relapsed or refractory low-grade B...
Demystifying Proteomics in Hematology
The central dogma of molecular biology describes the flow of information in a cell, from the DNA in a gene to RNA to protein....
Demystifying Genetic Testing for Bleeding Disorders
When hemophilia and von Willebrand disease (vWD) were first recognized, doctors didn’t diagnose a patient until he (or, much more infrequently, she) experienced a...
Demystifying Multicolor Flow Cytometry
Flow cytometry has come a long way in the 80 years since its inception. The now highly sophisticated technique is an indispensable tool for...
Demystifying Epigenetics in Hematology
In the early 20th century, German researcher Theodor Boveri described the basic tenets of tumor biology: Cells can turn cancerous when they lose the...
Demystifying Liquid Biopsies
Tumor biopsies have long been the standard method for diagnosing, monitoring, and treating cancer and, in the era of precision medicine, molecular analyses of...
Current Issue
May 2021 Volume 7 Issue 6
This issue provides an update on gene therapies in hematology, demystifies RNA sequencing, and more.