Red Blood Cell & Iron Disorders

Red Blood Cell & Iron Disorders

A collection of features and news articles published in ASH Clinical News related to red blood cell and iron disorders.

Sickle cell anemia

First CRISPR Trial for Patients with Severe Sickle Cell Disease to Begin

Scientists at the University of California (UC) Berkeley, the University of California San Francisco (UCSF), and the University of California Los Angeles (UCLA) have...

Transplant Improves Health-Related Quality of Life for Patients With SCD and Transfusion-Dependent Thalassemia

Hematopoietic cell transplantation (HCT) is associated with significant improvements in health-related quality of life (HRQoL) in patients with sickle cell disease (SCD) and transfusion-dependent...

Scientists Say LentiGlobin Not Linked to Cancer

On February 24, the U.S. Food and Drug Administration (FDA) placed a clinical hold on all LentiGlobin gene therapy trials following an announcement that...

Novartis and the Gates Foundation Collaborate on Off-the-Shelf Gene Therapy for Sickle Cell Disease

Novartis and the Bill and Melinda Gates Foundation are collaborating on a one-step, one-time gene therapy for patients with sickle cell disease (SCD). The...

Older Age, Pre-Existing Comorbidities Increase Poor Outcomes in Patients With SCD and COVID-19

Patients with sickle cell disease (SCD) have poor outcomes associated with COVID-19, particularly if they are older or present with end organ damage, acute...
On location

e-IRON: Iron-Deficiency Anemia Management at Warp Speed

A telemedicine pilot program to triage and expedite the management of patients with iron-deficiency anemia (IDA) who require intravenous (IV) iron allowed clinicians to...

Pegcetacoplan Improves Hematologic Response in PNH Treated With Eculizumab

For patients with paroxysmal nocturnal hemoglobinuria (PNH) who are receiving eculizumab yet have residual anemia, treatment with pegcetacoplan led to broad hemolysis control and...
On location

Fostamatinib Improves Hemoglobin Levels in Warm Autoimmune Hemolytic Anemia

Treatment with the oral Syk inhibitor fostamatinib led to “markedly improved” hemoglobin (Hb) levels in patients with warm autoimmune hemolytic anemia (wAIHA), according to...

A Primer on Porphyrias

Finding New Treatments for These Rare, Often Misdiagnosed, Disorders About 30 years ago, Michael Linenberger, MD, then a junior faculty hematologist, and his colleagues at...
Sickle cell anemia

First Patients to Receive CRISPR for SCD, Beta Thalassemia Continue to Improve

Updated results published in the New England Journal of Medicine and presented at the 2020 American Society of Hematology (ASH) Annual Meeting show that...
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April 2021 Volume 7 Issue 5

This issue examines long-haul COVID-19, central nervous system relapse in non-Hodgkin lymphoma, and more.

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