Red Blood Cell & Iron Disorders

Red Blood Cell & Iron Disorders

A collection of features and news articles published in ASH Clinical News related to red blood cell and iron disorders.

Sickle cell anemia

First Patients to Receive CRISPR for SCD, Beta Thalassemia Continue to Improve

Updated results published in the New England Journal of Medicine and presented at the 2020 American Society of Hematology (ASH) Annual Meeting show that...

FDA Clears Graphite Bio to Begin Trial for Gene Therapy in Sickle Cell Disease

In response to Graphite Bio’s investigational new drug (IND) application for its gene editing therapy, GPH101, the FDA will allow the pharmaceutical company to...
On location

Long-Term BELIEVE Analysis Finds Luspatercept Alleviates Transfusion Burden in Beta Thalassemia

A longitudinal analysis of data from the phase III BELIEVE trial showed that treatment with the activin receptor ligand trap luspatercept was associated with...

Nichola Cooper: Fostamatinib in Warm Antibody Autoimmune Hemolytic Anemia

Patients with warm antibody autoimmune hemolytic anemia (wAIHA) had markedly improved hemoglobin levels after fostamatinib treatment. Here, Nichola Cooper, MD, shares results from a phase...
On location

Roxadustat Superior to Epoetin Alfa in Patients With Anemia and Dialysis-Dependent Chronic Kidney Disease

In patients with anemia and dialysis-dependent chronic kidney disease (CKD), treatment with roxadustat led to higher hemoglobin (Hb) levels and a reduced need for...

Lydia Pecker: Hydroxyurea and Diminished Ovarian Reserve in Young Patients with Sickle Cell Anemia

Here, Lydia Pecker, MD, shares findings from a pilot study investigating whether young women with sickle cell anemia have lower antimullerian hormone than age-...

CSL889 Receives Orphan Drug Designation for SCD

The FDA and the European Commission have granted orphan drug designation to CSL889, a plasma-derived hemopexin therapy, for the treatment of sickle cell disease...
You Make the Call

You Make the Call: Can I start cytoreductive therapy in a patient with low-risk...

This month, Ayalew Tefferi, MD, discusses cytoreductive therapy in a patient with low-risk polycythemia vera. And don't forget to check out next month's clinical dilemma...
How I Treat In Brief

How I Treat Cancer-Associated Anemia

This month, Jeffrey A. Gilreath, PharmD, and George M. Rodgers, MD, PhD, review common and complex scenarios in the management of anemic patients with cancer. This...

NASEM Releases Sickle Cell Disease Report

The National Academies of Sciences, Engineering, and Medicine (NASEM) recently released a report titled “Addressing Sickle Cell Disease: A Strategic Plan and Blueprint for...
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Current Issue

January 2021 Annual Meeting Edition

This issue features highlights from the 2020 ASH Annual Meeting, a look at patient holiday gift customs around the world, and more.

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