Red Blood Cell & Iron Disorders

Red Blood Cell & Iron Disorders

A collection of features and news articles published in ASH Clinical News related to red blood cell and iron disorders.

Sickle cell anemia

Voxelotor Granted Priority Review for Children With Sickle Cell Disease

The U.S. Food and Drug Administration (FDA) has accepted Global Blood Therapeutics’ (GBT’s) supplemental New Drug Application (sNDA) seeking accelerated approval for voxelotor for...

Conserving Red Blood Cell Units in the Treatment of Patients With SCD During Blood...

The ongoing COVID-19 pandemic has led to severe blood shortages within the health care delivery system, disproportionately affecting the supply of red blood cells...

FDA Committee Votes Against Approval of Roxadustat for Anemia of Chronic Kidney Disease

The FDA’s Cardiovascular and Renal Drugs Advisory Committee (CRDAC) has decided not to recommend the approval of roxadustat for the treatment of patients with...
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Danicopan Improves Hemoglobin, Reduces Transfusion Requirements in Eculizumab-Treated Patients With PNH

First-in-class oral factor D inhibitor danicopan improved hemoglobin (Hb) and reduced transfusion requirements in transfusion-dependent patients with paroxysmal nocturnal hemoglobinuria (PNH) who had previously...
On location

PDE9 Inhibitor Shows Promise as Monotherapy and With Hydroxyurea in Sickle Cell Disease

Data from two new studies indicated that daily dosing of the oral phosphodiesterase type 9 (PDE9) inhibitor IMR-687, at doses up to 200 mg,...

Study Finds Specialized Infusion Centers Offer Better Care for Patients with SCD

A new study published in the Annals of Internal Medicine found that patients with sickle cell disease (SCD) experiencing acute pain crises received better...

Pegcetacoplan Approved for Paroxysmal Nocturnal Hemoglobinuria

The U.S. Food and Drug Administration (FDA) has approved the targeted C3 inhibitor pegcetacoplan for the treatment of adult patients with paroxysmal nocturnal hemoglobinuria...

Sickle Cell Trait Cited in Police Custody Deaths

In a review of data on suspicious deaths from more than 30 of the largest U.S. counties, The New York Times found that sickle...

More COVID-19 Complications Seen in Black Patients With Sickle Cell Disease and Sickle Cell...

Patients with sickle cell disease (SCD) and sickle cell trait (SCT) have significantly higher rates of hospitalization, pneumonia, and pain related to COVID-19 compared...

Improving Sickle Cell Disease Outcomes in Sub-Saharan Africa Starts With Screening

For patients with sickle cell disease (SCD) living in sub-Saharan Africa, early intervention drastically improves long-term health outcomes, but challenges around funding, training, and...
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Current Issue

September 2021 Volume 7 Issue 11

This issue discusses fertility preservation for young patients with cancer, reviews treatment options for primary immune thrombocytopenia, and more.

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