On Location

On Location

Updates from major medical meetings in the field of hematology/oncology

On location

Caplacizumab Produces Faster, Sustained Platelet Count Responses Than Placebo in aTTP

Patients with acquired thrombotic thrombocytopenic purpura (aTTP) who were treated with caplacizumab – anti–von Willebrand factor humanized immunoglobulin – experienced a faster and more...
On location

Isatuximab Plus Carfilzomib: A New Standard for Relapsed/Refractory Myeloma?

The three-drug combination of the CD38-targeting antibody isatuximab plus carfilzomib and dexamethasone significantly improved progression-free survival (PFS) in patients with relapsed or refractory multiple...
On location

Idecabtagene Vicleucel Demonstrates Deep, Durable Responses in Relapsed/Refractory Myeloma

The BCMA-targeted chimeric antigen receptor (CAR) T-cell therapy idecabtagene vicleucel (previously known as bb2121) induced responses in nearly three-quarters of patients with relapsed/refractory multiple...
On location

ANDROMEDA: Subcutaneous Daratumumab for Newly Diagnosed Light Chain Amyloidosis

Adding subcutaneous daratumumab to the combination of cyclophosphamide, bortezomib, and dexamethasone (CyBorD) resulted in deeper and more rapid hematologic responses and improved clinical outcomes,...
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A New CAR T-Cell Target for T-Cell Acute Lymphocytic Leukemia?

The anti-CD7 chimeric antigen receptor (CAR) T-cell therapy TruUCAR GC027 demonstrated promising efficacy in treating adults with relapsed or refractory T-cell acute lymphoblastic leukemia...
On location

Adding Venetoclax to Azacitidine Improves Response and Survival Rates in Treatment-Naïve AML

A combination of the hypomethylating agent azacitidine and the small-molecule BCL2 inhibitor venetoclax was associated with a 34% reduction in the risk of death,...
On location

Ibrutinib Improves Response and Survival Rates in CNS Relapse of Mantle Cell Lymphoma

Compared with standard immunochemotherapy, treatment with ibrutinib was associated with higher response rates and survival rates in patients with mantle cell lymphoma (MCL) and...
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Pegcetacoplan Outperforms Eculizumab for Paroxysmal Nocturnal Hemoglobinuria

Results from the phase III PEGASUS trial suggest that the targeted C3 inhibitor pegcetacoplan improved hemoglobin levels better than eculizumab in patients with paroxysmal...
On location

Evaluating MBG453 Plus Decitabine or Azacitidine in High-Risk MDS and AML

The anti-TIM-3 checkpoint inhibitor MBG453, when added to decitabine or azacitidine, was associated with antileukemic activity and durable response rates in patients with higher-risk...
On location

Systemic Bevacizumab Improves Anemia, Reduces Bleeding in Hereditary Hemorrhagic Telangiectasia

Treatment with systemic bevacizumab reduced bleeding and significantly increased hemoglobin levels in patients with the rare bleeding disorder hereditary hemorrhagic telangiectasia (HHT), according to...
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November 2020 Bonus ASH Annual Meeting Preview Edition (Volume 6, Issue...

View issue flipbook November 2020 Bonus ASH Annual Meeting Preview Edition Volume 6, Issue 14This issue offers a behind-the-scenes look at this year's virtual annual meeting,...

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