Literature Scan

Literature Scan

New and noteworthy research from the medial literature landscape

Female Underrepresentation Persists Among Patients Enrolled in Hematologic, Solid Tumor Trials

While clinical trials have increasingly included female participants over the past 40 years, women are underrepresented in clinical trials of cancer treatments compared with...

Optimizing Outcomes With Azacitidine Treatment in Patients With MDS

Delays in treatment with azacitidine predicted lower survival rates in patients with myelodysplastic syndromes (MDS), independently of the International Prognostic Scoring System (IPSS) score...

Fostamatinib More Effective Earlier in Treatment for Immune Thrombocytopenia

Fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, was more effective and had similar safety when used as a second-line therapy, rather than as a...

Ixazomib Maintenance Delays Progression in Non-Transplanted Patients With Newly Diagnosed Myeloma

Postinduction maintenance therapy with the oral proteasome inhibitor ixazomib prolonged progression-free survival (PFS) in patients with newly diagnosed multiple myeloma (MM) who were not...

Treatment With Caplacizumab Allows Patients to Delay or Omit Plasma Exchanges

Treatment of acquired thrombotic thrombocytopenic purpura (aTTP) with caplacizumab, but without plasma exchange, increased platelet counts and improved surrogate parameters of organ damage in...

Pediatric-Inspired Pegaspargase Regimen Shows Promise for Treatment of ALL/LBL

A pediatric-inspired treatment regimen incorporating pegaspargase timed to avoid overlapping toxicities was associated with manageable toxicity, high measurable residual disease (MRD) negativity rates, and...

Addition of Elotuzumab Prolongs Survival in Relapsed or Refractory Myeloma

Treatment with elotuzumab plus lenalidomide and dexamethasone (ERd) was associated with significant and clinically meaningful reductions in mortality risk, compared with lenalidomide and dexamethasone...

Fresh Frozen Plasma May Help Maintain Successful Pregnancy in Women With Congenital TTP

Prophylactic fresh frozen plasma (FFP) infusions may be necessary to replenish ADAMTS13 activity and maintain a successful pregnancy in expectant mothers with congenital thrombotic...

Smokeless Tobacco Linked to Subtherapeutic INR in Warfarin-Treated Patient

Failure to achieve a therapeutic international normalized ratio (INR) with warfarin was associated with chronic exposure to vitamin K-rich smokeless chewing tobacco in a...

Evaluating the TP53 State and Its Implications for Myelodysplastic Syndromes Outcomes

In a new study published in Nature Medicine, researchers evaluated the effect of the TP53 allelic state on the clinical presentation and outcomes of...
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May 2021 Volume 7 Issue 6

This issue provides an update on gene therapies in hematology, demystifies RNA sequencing, and more.

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