Literature Scan

Literature Scan

New and noteworthy research from the medial literature landscape

Newer TKIs Versus Imatinib in CML-CP Patients

With the emergence of second-generation tyrosine kinase inhibitors (TKIs), more choices than ever exist for treating patients with chronic-phase chronic myeloid leukemia (CML-CP). However,...

Do Clinical Trials Underreport Cancer Drug Toxicities?

Clinical trials may be underreporting patient toxicities from cancer drugs – by up to 75 percent in some cases – according to a new...

Order of Gene Mutation: Predicting What Cancer Will Do Next

Over the last decade, scientists have gained a much greater understanding of which genes acquire mutations in particular cancers. Now, new research is showing...

Can Genetic Sequencing Provide Insights into Disease and Hematopoiesis?

Sequencing of genomic data is increasingly becoming a valuable tool in identifying disease etiology in diagnostically challenging cases, as one research team discovered while...

A Zebrafish and Enhanced Imaging Captures How Blood Stem Cells Take Root

A research team from Boston Children Hospital’s Stem Cell Research Program has provided the first direct glimpse into how blood stem cells take root...

The Debate Rages on: Is Omitting Radiation Therapy from Hodgkin Lymphoma Good for Patients?

Although Hodgkin lymphoma (HL) is frequently treated with a combination of chemotherapy and radiation therapy, there is a movement towards omitting radiation therapy altogether....

Is It Time to Reconsider Allogeneic SCT in NPM1-Mutant AML?

Allogeneic stem cell transplantation (SCT) significantly improved rates of relapse-free survival (RFS), but not overall survival (OS) in patients with acute myeloid leukemia (AML)...

New Agent PER977 Shows Promise in Reversing Anticoagulation

Although newer target-specific oral anticoagulants represent great advances in the prevention and treatment of blood clots, their use is limited by a lack of effective reversal agents. Severe...

Many Younger Patients Receive Inappropriate First-Line Care

Nearly one-third of adolescent and young adult patients diagnosed with cancer do not receive appropriate therapy, according to recent research published in the Journal of the National Cancer Institute. The...

Panobinostat Improves Survival in Multiple Myeloma: Results from PANORAMA1

A three-drug combination with panobinostat significantly increased median progression-free survival (PFS) in patients with relapsed/refractory multiple myeloma. Adding panobinostat to the multiple myeloma treatment...
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October 2019, Volume 5, Issue 12

This issue highlights the unintended consequences of fighting the nation’s opioid epidemic, considers the optimal frontline regimen for myeloma, and more.