Written in Blood

Written in Blood

Research from recent issues of Blood

WIB_icon

Novel JAK2 Insertion/Deletion Mutation Associated With Unique MPN Overlap Syndrome

In a small study of patients with myeloproliferative neoplasms (MPNs), a novel JAK2 insertion/deletion mutation, which the investigators termed JAK2ex13InDel, was found to drive...
WIB_icon

Updates From ECHELON-1: Brentuximab Vedotin Provides Durable Efficacy in Hodgkin Lymphoma

Previously reported results from the phase III ECHELON-1 trial suggested that replacing bleomycin with brentuximab vedotin in the standard ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)...
WIB_icon

Achievement of MRD Negativity Predicts Favorable Prognosis in RUNX1-RUNX1T1+ AML

In patients with acute myeloid leukemia (AML) with t(8;21)(q22;q22.1)/RUNX1-RUNX1T1+ fusion, serial assessment of measurable residual disease (MRD) can identify people at a high risk...
WIB_icon

Study Highlights Role of Complement Activation in Antiphospholipid Syndrome

Treatment of patients with antiphospholipid syndrome (APS), a disease characterized by thrombosis and pregnancy morbidity and mortality, is hindered by an incomplete understanding of...
WIB_icon

Emicizumab Lowers Bleeding Rates in Children With Hemophilia A and Inhibitors

Once-weekly treatment with emicizumab prophylaxis led to low bleeding rates in children with hemophilia A and factor VIII (FVIII) inhibitors, with more than three-quarters...
WIB_icon

Moderate-Intensity Endurance Training Improves Skeletal Microvasculature in Patients with Sickle Cell Disease

An endurance exercise training program of moderate intensity may reverse some of the microvascular deficits of skeletal microvasculature in patients with sickle cell disease...
WIB_icon

The Fewer Transfusions, the Better for Newborns With Thrombocytopenia

Newborns with thrombocytopenia had a lower risk of death or bleeding if they received platelet transfusions according to a lower 25×109/L threshold rather than...
WIB_icon

Twin Study Finds No Genetic Predisposition to Clonal Hematopoiesis

In a study published in Blood, researchers found no concordance in somatic clonal hematopoiesis (CH) mutations in a cohort of older twins, indicating that...
WIB_icon

Older Patients with iTTP Have Delayed Diagnosis and Higher Mortality Than Younger Counterparts

Older patients diagnosed with immune thrombotic thrombocytopenic purpura (iTTP) have worse short- and long-term mortality compared with younger patients and the general population, according...
WIB_icon

Eltrombopag Induces Complete Platelet Responses in Patients with Lymphoproliferative Disorders and Treatment-Resistant ITP

Results from a small phase II trial suggest that treatment with eltrombopag was associated with sustained platelet responses and complete responses (CRs) in patients...
Advertisement

Current Issue

May 2020, Volume 6, Issue 6

This issue discusses AI's potential to improve patient care, debates using donors with clonal hematopoiesis for alloHCT, and more.