Asciminib Superior to Bosutinib in Chronic-Phase CML
Asciminib was more effective than bosutinib at improving the rate of a major molecular response in patients with chronic myeloid leukemia in chronic phase...
Flow Cytometry as a Prognostic Tool for Children With Down Syndrome and AML
The use of flow cytometry alone to determine measurable residual disease (MRD) status did not sufficiently identify children with acute myeloid leukemia (AML) and...
Blunted Response to COVID-19 Vaccines in Transplant and Cellular Therapy Recipients
Many patients who undergo bone marrow transplant and CAR-T cell therapy do not mount a detectable humoral response to authorized COVID-19 vaccines, according to...
Belumosudil Induces Responses in Refractory Chronic Graft-Versus-Host Disease
Belumosudil, a selective Rho-associated coiled-coil–containing protein kinase-2 (ROCK2) inhibitor, was associated with organ responses in heavily pretreated patients with chronic graft-versus-host disease (cGVHD) that...
Danicopan Improves Hemoglobin, Reduces Transfusion Requirements in Eculizumab-Treated Patients With PNH
First-in-class oral factor D inhibitor danicopan improved hemoglobin (Hb) and reduced transfusion requirements in transfusion-dependent patients with paroxysmal nocturnal hemoglobinuria (PNH) who had previously...
Omidubicel Improves Outcomes, Reduces Hospital Stay for Patients with Hematologic Malignancies
Patients with hematologic malignancies who received umbilical cord blood transplantation with omidubicel engrafted faster, had fewer infections, and spent less time in the hospital, compared...
Gene Therapy Shows Durable Efficacy in Young Patients With ADA Severe Combined Immune Deficiency
Recent results published in Blood suggest gene therapy could offer an alternative to transplant for young patients with adenosine deaminase (ADA) severe combined immune...
Survival Outcomes After HLA-Haploidentical Relative Versus Matched Unrelated Donor Transplant in Acute Leukemias and...
In patients with acute leukemias or myelodysplastic syndromes (MDS), those who underwent haploidentical relative hematopoietic cell transplantation (haploHCT) had higher rates of grade 3-4...
Less-Intensive Therapies Increase Mortality Risk, But Decrease Hospital Stay, in Older Patients With AML
Although the use of less-intensive therapies is associated with an increased risk of mortality in older patients with acute myeloid leukemia (AML), patients treated...
Is Gene Therapy Cost-Effective for Hemophilia B?
A study published in Blood found the use of gene therapy for hemophilia B to be more cost-effective than prophylaxis or on-demand treatment with...
Current Issue
September 2021 Volume 7 Issue 11
This issue discusses fertility preservation for young patients with cancer, reviews treatment options for primary immune thrombocytopenia, and more.