Updates From ECHELON-1: Brentuximab Vedotin Provides Durable Efficacy in Hodgkin Lymphoma
Previously reported results from the phase III ECHELON-1 trial suggested that replacing bleomycin with brentuximab vedotin in the standard ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)...
Achievement of MRD Negativity Predicts Favorable Prognosis in RUNX1-RUNX1T1+ AML
In patients with acute myeloid leukemia (AML) with t(8;21)(q22;q22.1)/RUNX1-RUNX1T1+ fusion, serial assessment of measurable residual disease (MRD) can identify people at a high risk...
Study Highlights Role of Complement Activation in Antiphospholipid Syndrome
Treatment of patients with antiphospholipid syndrome (APS), a disease characterized by thrombosis and pregnancy morbidity and mortality, is hindered by an incomplete understanding of...
Emicizumab Lowers Bleeding Rates in Children With Hemophilia A and Inhibitors
Once-weekly treatment with emicizumab prophylaxis led to low bleeding rates in children with hemophilia A and factor VIII (FVIII) inhibitors, with more than three-quarters...
Moderate-Intensity Endurance Training Improves Skeletal Microvasculature in Patients with Sickle Cell Disease
An endurance exercise training program of moderate intensity may reverse some of the microvascular deficits of skeletal microvasculature in patients with sickle cell disease...
The Fewer Transfusions, the Better for Newborns With Thrombocytopenia
Newborns with thrombocytopenia had a lower risk of death or bleeding if they received platelet transfusions according to a lower 25×109/L threshold rather than...
Twin Study Finds No Genetic Predisposition to Clonal Hematopoiesis
In a study published in Blood, researchers found no concordance in somatic clonal hematopoiesis (CH) mutations in a cohort of older twins, indicating that...
Older Patients with iTTP Have Delayed Diagnosis and Higher Mortality Than Younger Counterparts
Older patients diagnosed with immune thrombotic thrombocytopenic purpura (iTTP) have worse short- and long-term mortality compared with younger patients and the general population, according...
Eltrombopag Induces Complete Platelet Responses in Patients with Lymphoproliferative Disorders and Treatment-Resistant ITP
Results from a small phase II trial suggest that treatment with eltrombopag was associated with sustained platelet responses and complete responses (CRs) in patients...
Study Identifies Familial Risk Patterns of Several Hematologic Malignancies
People who have a first-degree relative diagnosed with a hematologic malignancy have a higher risk of developing a blood cancer, according to an analysis...
Current Issue
January 2020 Annual Meeting Edition
This issue features highlights from the 2019 ASH Annual Meeting, reflections on physician wellness, and more.
