Small Retrospective Study Suggests Thrombopoietin Receptor Agonists Are Safe, Likely Effective for ITP During...
Preliminary findings from an observational multicenter study suggest that temporary off-label use of thrombopoietin receptor agonists (TPO-RAs) for the treatment of severe and/or refractory...
ART and PrEP May Present Challenges in Detecting HIV Infection in Blood Donations
While antiretroviral (ARV) drugs and pre-exposure prophylaxis (PrEP) are effective tools to help reduce the burden of HIV, a new study published in Blood...
Bispecific Immune Cell Engager AFM13 Plus Pembrolizumab Produces High Responses in Heavily Treated Hodgkin...
In a phase Ib study published in Blood, treatment with AFM13, a CD30/CD16A bispecific tetravalent innate immune cell engager, was safe and produced promising...
Large Study Identifies Predictors of Inferior Survival in Patients With Burkitt Lymphoma
A retrospective analysis of data from 30 U.S. cancer centers found that adults with newly diagnosed Burkitt lymphoma (BL) have modest survival rates and...
Geriatric Assessment Identifies Risk Factors for Worse Survival in Older Adults With AML
Older patients with acute myeloid leukemia (AML) who undergo post-remission therapy may be at risk of poor survival if they present with impaired physical...
Inflammatory Biomarkers at Presentation May Predict Thrombosis in COVID-19
Researchers from Massachusetts General Hospital in Boston have identified several markers at presentation that predict coagulation-associated complications in patients with COVID-19: elevated D-dimer, C-reactive...
Lenzilumab Demonstrates Clinical Benefit in Patients With Chronic Myelomonocytic Leukemia
A phase I study found that lenzilumab, an engineered human IgG1K monoclonal antibody that neutralizes granulocyte-macrophage colony-stimulating factor (GM-CSF), was associated with a clinical...
Radiation Alone Improves Outcomes in Early-Stage NLPHL Without High-Risk Features
Radiotherapy alone was associated with excellent progression-free survival (PFS) and low rates of late toxicity in patients with stages IA to IIA nodular lymphocyte-predominant...
Prophylaxis Does Not Fully Prevent VTE Risk in Patients With ALL Treated With Asparaginase
Antithrombin (AT) replacement and heparin prophylaxis was not entirely effective for the prevention of venous thromboembolism (VTE) in adult patients with acute lymphocytic leukemia...
International Prognostic Score Predicts Time to First Treatment in Patients With Early-Stage CLL
An international prognostic score (IPS-E) consisting of a sum score for three markers for consistently predicted time to first treatment (TTFT) in patients with...
Current Issue
September 2020 Volume 6, Issue 11
This issue features a look at the evolution of preprint platforms, an analysis of the economic and health consequences of the COVID-19 pandemic, and more.