Idiopathic Multicentric Castleman Disease: Identifying Prevalence and New Treatment Targets
Two recent studies published in Blood Advances explored idiopathic multicentric Castleman disease (iMCD). Researchers led by Sudipto Mukherjee, MD, MPH, of Cleveland Clinic, provided...
Long-Term Hydroxyurea May Improve Cardiac Abnormalities in Young Patients With Sickle Cell Disease
Long-term hydroxyurea therapy in children with sickle cell disease (SCD) may reverse cardiac remodeling, according to new research findings. Lead study author Arushi Dhar,...
Intravenously Administered CD19-Directed CAR T Cells Safe, Potentially Effective in Primary CNS Lymphoma
Intravenously administered CD19-directed chimeric antigen receptor (CAR) T-cell therapy was found to be safe and associated with high levels of complete remission (CR) in...
Germline Variants in DNA Repair Pathway Genes May Trigger Familial MPNs
Germline variants in DNA repair pathway genes, such as BRCA1/2, may trigger familial myeloproliferative neoplasms (MPNs), suggesting these variants should be incorporated in diagnostic...
Modified EASIX Score Predicts CRS and ICANS Before Severe Symptoms in Patients With B-Cell...
A modified version of the EASIX (Endothelial Activation and Stress Index) score, when calculated prior to and soon after chimeric antigen receptor (CAR) T-cell...
Rituximab Biosimilars Versus Originator: Comparing Long-Term Survival Benefit in DLBCL
A study published in Blood Advances found the three-year rate of overall survival (OS) was similar between Dutch patients with diffuse large B-cell lymphoma...
Early Catheter Removal Does Not Increase Risk of PE
Among patients with a hematologic malignancy and central venous catheter (CVC)–associated upper extremity deep vein thrombosis (UEDVT), removing CVCs within 48 hours of diagnosis...
rFIXFc as Prophylaxis and Treatment in Pediatric Hemophilia B
Results from the phase III B-LONG study published in Blood Advances found that recombinant factor IX Fc fusion protein (rFIXFc) was an effective prophylactic...
Treatment Delays and Hemostatic Abnormalities Predict Death in Newly Diagnosed APL
Major factors associated with early deaths in hospitalized patients with newly diagnosed acute promyelocytic leukemia (APL) included treatment delays and the incidence of hemostatic...
Conserving Red Blood Cell Units in the Treatment of Patients With SCD During Blood...
The ongoing COVID-19 pandemic has led to severe blood shortages within the health care delivery system, disproportionately affecting the supply of red blood cells...
Current Issue
November 2021 Bonus ASH Annual Meeting Preview Edition
This issue offers a behind-the-scenes look at this year's annual meeting, and more.