LentiGlobin Gene Therapy Possibly Safe for Severe Sickle Cell Disease
Interim data from a phase I study of LentiGlobin BB305 in patients with severe sickle cell disease (SCD) suggest that the gene therapy was...
Expanding Acalabrutinib to Waldenström Macroglobulinemia
Roger Owen, MRCP, MRCPath, MD, presents phase II data of the selective Bruton tyrosine kinase inhibitor, which showed “exceptional response rates” in both treatment-naïve...
Weekly Carfilzomib Dosing Superior to Twice-Weekly Dosing
James Berenson, MD, discusses results from a trial evaluating less-frequent dosing of carfilzomib for patients with myeloma. Once-weekly dosing was superior, but the mechanisms...
Enhancing Ibrutinib With Rituximab in Waldenström Macroglobulinemia
Combining ibrutinib with rituximab led to longer progression-free survival, compared with ibrutinib alone, in patients with Waldenström macroglobulinemia. Meletios Dimopoulos, MD, shares results from...
Does Blinatumomab Affect CAR T-Cell Therapy Response?
In new data from ZUMA-3, patients with acute lymphocytic leukemia responded to CD19-targeting CAR T-cell therapy, regardless of prior CD19-targeting therapy with blinatumomab. Bijal...
Venetoclax Plus Carfilzomib: A New Wave of Myeloma Treatment
Luciano Costa, MD, talks about the combination of venetoclax and carfilzomib, which led to an 83% response rate in patients with relapsed and heavily-refractory...
With bb2121, Is CAR T-Cell Therapy Ready for Myeloma?
Noopur Raje, MD, discusses updated data from a phase I trial of the second-generation, anti-BCMA CAR T-cell therapy for relapsed/refractory myeloma.
“Best Survival Data Yet” With Nelarabine in T-Cell ALL
Kimberly P. Dunsmore, MD, discusses results from the largest trial conducted of young patients with newly diagnosed T-cell acute lymphocytic leukemia, which produced survival...
Positive Results With Ivosidenib in IDH1-Mutated AML
Treatment with the highly selective IDH1 inhibitor ivosidenib led to a complete remission rate of 40%, with an overall survival of nearly 19 months...
Allogeneic Transplant Plus NK Cells in High-Risk Myeloma
Dr. Shah discusses natural killer cells for myeloma - a cellular therapy that "kills" without causing graft-versus-host disease.
Current Issue
November 2018, Volume 4, Issue 13
This issue features a look at the U.S. drug pricing system, attempts to solve physician burnout, and more.
