MDS & Myeloproliferative Neoplasms

MDS & Myeloproliferative Neoplasms

A collection of features and news articles published in ASH Clinical News related to myelodysplastic syndromes and myeloproliferative neoplasms.

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Evaluating MBG453 Plus Decitabine or Azacitidine in High-Risk MDS and AML

The anti-TIM-3 checkpoint inhibitor MBG453, when added to decitabine or azacitidine, was associated with antileukemic activity and durable response rates in patients with higher-risk...

FDA Approves Decitabine and Cedazuridine Combination for MDS

The FDA approved an oral combination of decitabine and cedazuridine for adults with myelodysplastic syndromes (MDS), including: those with previously treated and untreated, de...
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CC-486 Improves Transfusion Independence in MDS, but Adverse Events Are Common

For patients with lower-risk myelodysplastic syndromes (MDS) and both red blood cell (RBC) transfusion-dependent anemia and thrombocytopenia, CC-486, an oral formulation of the hypomethylating...
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IWG-PM Publishes Proposed Diagnostic Criteria for SF3B1-Mutant MDS

The International Working Group for the Prognosis of MDS (IWG-PM) has published a proposal for new diagnostic criteria for SF3B1-mutant myelodysplastic syndromes (MDS) as...

Luspatercept-aamt Approved for Anemia in Adults With MDS

The FDA has approved luspatercept-aamt for the treatment of anemia that requires 2 or more red blood cell transfusions over 8 weeks in adults...

Putting Mutation Testing in Myeloid Malignancies to the Test

In 2014, the World Health Organization (WHO) convened a clinical advisory committee to begin updating and revising the existing classification of myeloid neoplasms (MPNs)...

Chk1 Inhibition Shows Efficacy for Splicing Factor Mutant MDS and Leukemia

A new study found Chk1 inhibition with or without splicing modulators may be an effective targeted treatment approach for splicing factor mutant myelodysplastic syndromes...

Luspatercept Reduces Anemia Severity, Improves Rate of Transfusion Independence in MDS

Compared with placebo, treatment with luspatercept improved the 12- to 16-week rate of red blood cell (RBC) transfusion independence in patients with lower-risk myelodysplastic...

FDA Grants Breakthrough Designation to APR-246 for MDS

The FDA granted breakthrough therapy designation to APR-246 in combination with azacitidine for the treatment of patients with myelodysplastic syndromes (MDS) and a TP53...
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Patients With SCD and TP53 Mutations May Develop Myeloid Malignancy After Unsuccessful AlloHCT

Population studies have shown that patients with sickle cell disease (SCD) who have undergone an unsuccessful allogeneic hematopoietic cell transplantation (alloHCT) have an increased...
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Current Issue

August 2020 Volume 6, Issue 10

This issue looks at the rapid expansion of telemedicine, explores access to leukemia treatment in Brazil, and more.