Clotting Disorders

Clotting Disorders

A collection of features and news articles published in ASH Clinical News related to clotting disorders.

NIH’s ACTIV Trial Suspends Enrollment of Critically Ill Patients With COVID-19

The National Institutes of Health (NIH) announced that it is pausing enrollment of patients with severe COVID-19 in three trials that are evaluating anticoagulants...
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Is Caplacizumab a Cost-Effective Strategy for Acquired TTP?

In February 2019, the FDA approved the anti–von Willebrand factor immunoglobulin fragment caplacizumab as the only agent specifically indicated for the treatment of adults...
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In Utero Hematopoietic Cell Transplantation Safe in Fetuses with Alpha Thalassemia Major

In utero hematopoietic cell transplantation (IUHCT) with maternal cells was safe in two fetuses with alpha thalassemia major (ATM), according to interim results of...
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Testing for Inherited Thrombophilias Provides Limited Benefit

Inherited thrombophilias are associated with an increased risk of initial and recurrent venous thromboembolism (VTE), but testing for these conditions in the setting of...

Normal Results on D-Dimer Testing Can Safely Rule out Deep Vein Thrombosis

A simplified approach of an initial stand-alone D-dimer test followed by a single whole-leg compression ultrasound (CUS) in D-dimer positive patients can effectively and...
You Make the Call

You Make the Call: How would you treat this patient with JAK2-positive essential thrombocythemia?

This month, Ruben Mesa, MD, discusses anticoagulation in a patient with essential thrombocythemia. And don't forget to check out next month's clinical dilemma - send...
You Make the Call

You Make the Call: Can I start cytoreductive therapy in a patient with low-risk...

This month, Ayalew Tefferi, MD, discusses cytoreductive therapy in a patient with low-risk polycythemia vera. And don't forget to check out next month's clinical dilemma...
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Immune Checkpoint Inhibitors May Increase Thromboembolism Risk

Patients with cancer who are treated with immune checkpoint inhibitors are at an increased risk of developing venous thromboembolism (VTE) and arterial thromboembolism (ATE),...

How Common Is Venous Thromboembolism in Patients Hospitalized With COVID-19?

Reports have suggested that venous thromboembolism (VTE) is a frequent complication of COVID-19 infection, and patients are at an increased thrombotic risk even with...

Smokeless Tobacco Linked to Subtherapeutic INR in Warfarin-Treated Patient

Failure to achieve a therapeutic international normalized ratio (INR) with warfarin was associated with chronic exposure to vitamin K-rich smokeless chewing tobacco in a...
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January 2021 Annual Meeting Edition

This issue features highlights from the 2020 ASH Annual Meeting, a look at patient holiday gift customs around the world, and more.

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