Clotting Disorders

Clotting Disorders

A collection of features and news articles published in ASH Clinical News related to clotting disorders.

FDA Requires Boxed Warning for Tofacitinib

The U.S. Food and Drug Administration (FDA) has issued a Safety Announcement requiring a boxed warning for the Janus kinase (JAK) inhibitor tofacitinib, indicating...
You Make the Call

What could provoke venous thromboembolisms in two teenaged siblings?

This month, Leslie J. Raffini, MD, discusses treating large venous thromboembolisms in two teenaged siblings. And don't forget to check out next month's clinical dilemma -...
You Make the Call

Readers’ Responses: What could provoke venous thromboembolisms in two teenaged siblings?

Here’s how readers responded to a You Make the Call question about large venous thromoembolisms in two teenaged siblings. Disclaimer: ASH does not recommend or...

Adding Pneumatic Compression to Heparin Therapy Does Not Reduce DVT in Critically Ill Patients

According to results from the PREVENT trial, adjunctive pneumatic compression plus pharmacologic thromboprophylaxis did not lower the risk of new lower-limb deep vein thrombosis...

Europe Poised to Approve Hydroxyurea for Sickle Cell Disease

Europe’s Committee for Medicinal Products for Human Use (CHMP) has recommended that the European Medicines Agency (EMA) grant marketing authorization to hydroxyurea for the...

FDA Alerts Patients About Blood Clot and Mortality Risk With Tofacitinib

The U.S. Food and Drug Administration (FDA) has issued a Safety Announcement for the Janus kinase (JAK) inhibitor tofacitinib after a required postmarketing trial...

Xarelto Manufacturers Settle Lawsuits Over Bleeding Risks

Johnson & Johnson and Bayer, the manufacturers of rivaroxaban (sold as Xarelto), have agreed to pay $775 million to settle thousands of lawsuits over...

FDA Approves Caplacizumab-yhdp for Acquired TTP

Caplacizumab-yhdp, a bivalent anti–von Willebrand factor nanobody, was approved for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with...

Planes, Trains, and VTEs

Simple recommendations can help mitigate risk for travel-related blood clots In November 2011, hematologist Suely Rezende, MD, PhD, deplaned from a flight from Lisbon to...

Roche Will Donate Hemophilia A Drug to Developing Countries

Roche will donate its new hemophilia A drug emicizumab-kxwh to the World Hemophilia Federation (WHF) Humanitarian Aid Program. Roche joins other companies – including...
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Current Issue

August 2019, Volume 5, Issue 10

August 2019, Volume 5, Issue 10

This issue features a debate about gun control as a health care issue, a look at blood services in Israel and Palestine, and more.