Bleeding Disorders

A collection of features and news articles published in ASH Clinical News related to bleeding disorders.

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Adding All-Trans Retinoic Acid to Low-Dose Rituximab in Corticosteroid-Resistant or Relapsed ITP

A combination regimen comprising all-trans retinoic acid (ATRA) plus low-dose rituximab was associated with an 80% overall response rate and a 61% sustained response...

Should Doppler Ultrasounds Be Performed on All Four Extremities in Patients With HIT?

American Society of Hematology (ASH) clinical practice guidelines released in 2018 recommend “discontinuation of heparin and initiation of non-heparin anticoagulant” for patients with newly...
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How Safe Is Vaccination Against SARS-CoV-2 for Patients With De Novo and Preexisting ITP?

A report describing the effects of SARS-CoV-2 vaccination on platelet counts of patients with de novo and preexisting immune thrombocytopenia (ITP), including findings of...

Mycophenolate Mofetil Plus Glucocorticoid Reduces Relapse Risk in ITP

Initial treatment with mycophenolate mofetil plus a glucocorticoid was associated with a greater response and reduced risk of relapsed or refractory disease compared with...
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Defining Incidence and Mortality Rates of Intracranial Hemorrhage in Patients With Hemophilia

Compared with the general population, intracranial hemorrhage (ICH) rates are higher in all patients with hemophilia, according to a study published in Blood. Reported...

Patient-Reported Outcome Questionnaire Shows Promise for Monitoring ITP

A draft version of a 10-item patient-reported outcome (PRO) questionnaire has been developed to evaluate the impact of immune thrombocytopenia (ITP) on patients and...

rFIXFc as Prophylaxis and Treatment in Pediatric Hemophilia B

Results from the phase III B-LONG study published in Blood Advances found that recombinant factor IX Fc fusion protein (rFIXFc) was an effective prophylactic...
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Corticosteroid-Dependent or Corticosteroid-Unresponsive Primary ITP

This month, Waleed Ghanima, MD, PhD, Terry Gernsheimer, MD, and David J. Kuter, MD, DPhil, review treatment options for adult patients with primary immune...
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Evaluating Two New Options for Hereditary Hemorrhagic Telangiectasia

At EHA2021 Virtual, researchers shared safety and efficacy findings of two agents for the treatment of the rare disease hereditary hemorrhagic telangiectasia (HHT): pazopanib...

Afibrinogenemia: A Rare, Often Overlooked Bleeding Disorder

Afibrinogenemia is a very rare, inherited blood disorder in which the blood does not clot normally because of a mutation that leads to the...