Bleeding Disorders

A collection of features and news articles published in ASH Clinical News related to bleeding disorders.

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Fitusiran Reduces Bleeding Risk in Patients With Hemophilia A or B Without Inhibitors

Once-monthly prophylactic treatment with subcutaneous fitusiran reduced the risk of bleeding in patients with severe hemophilia A or B without inhibitors, compared with once-daily...

Guy Young: Fitusiran for Hemophilia A and B With Inhibitors

Administration of prophylactic fitusiran significantly reduced annualized bleeding rates among patients with hemophilia A or B with inhibitors, translating to meaningful improvement in health-related...
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Emicizumab Improves Bleeding Prophylaxis in Patients With Acquired Hemophilia A

The FVIII-mimetic bispecific antibody emicizumab could provide effective and safe outpatient prophylaxis in patients with acquired hemophilia A (AHA), according to results of a...
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Fitusiran Significantly Reduced Bleeding in Hemophilia A and B With Inhibitors

Administration of prophylactic fitusiran significantly reduced annualized bleeding rates among patients with hemophilia A or B with inhibitors, according to the results of the...
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Evaluating the Safety and Efficacy of Rilzabrutinib in Relapsed/Refractory ITP

Treatment with the oral Bruton tyrosine kinase (BTK) inhibitor rilzabrutinib was well-tolerated and associated with durable, clinically significant responses in patients with heavily pretreated...
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Adding All-Trans Retinoic Acid to Low-Dose Rituximab in Corticosteroid-Resistant or Relapsed ITP

A combination regimen comprising all-trans retinoic acid (ATRA) plus low-dose rituximab was associated with an 80% overall response rate and a 61% sustained response...

Should Doppler Ultrasounds Be Performed on All Four Extremities in Patients With HIT?

American Society of Hematology (ASH) clinical practice guidelines released in 2018 recommend “discontinuation of heparin and initiation of non-heparin anticoagulant” for patients with newly...
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How Safe Is Vaccination Against SARS-CoV-2 for Patients With De Novo and Preexisting ITP?

A report describing the effects of SARS-CoV-2 vaccination on platelet counts of patients with de novo and preexisting immune thrombocytopenia (ITP), including findings of...

Mycophenolate Mofetil Plus Glucocorticoid Reduces Relapse Risk in ITP

Initial treatment with mycophenolate mofetil plus a glucocorticoid was associated with a greater response and reduced risk of relapsed or refractory disease compared with...
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Defining Incidence and Mortality Rates of Intracranial Hemorrhage in Patients With Hemophilia

Compared with the general population, intracranial hemorrhage (ICH) rates are higher in all patients with hemophilia, according to a study published in Blood. Reported...