Bleeding Disorders

Bleeding Disorders

A collection of features and news articles published in ASH Clinical News related to bleeding disorders.

FDA Approves New Hemophilia A Drug

The FDA has approved emicizumab-kxwh as prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients with hemophilia A...

Emicizumab Prophylaxis Reduces Bleeding Events in Hemophilia A Without Inhibitors

Treatment with emicizumab was associated with lower bleeding rates, compared with no prophylaxis, in patients with hemophilia A without inhibitors, according to findings from...

No Added Benefit When Hydroxyurea Is Combined With Aspirin in Middle-Aged Patients With Essential...

Cytoreductive treatment with hydroxyurea has been shown to reduce the risk of thrombosis in patients with essential thrombocythemia (ET) and high-risk features, which include...

FDA Approves New Treatment for Hemophilia

The U.S. Food and Drug Administration (FDA) approved BAY94-9027, or antihemophilic factor (recombinant), PEGylated-aucl, for the prophylactic treatment of adults and adolescents (≥12 years)...

Evaluating Twice-Yearly Denosumab for Transfusion-Dependent, Thalassemia-Induced Osteoporosis

Treatment with twice-yearly denosumab improved spinal bone mineral density (BMD) compared with placebo in patients with transfusion-dependent thalassemia (TDT)–induced osteoporosis, according to results of...

How to Treat Anemia in a Patient Who Refuses Transfusions for Religious Reasons

This month, Neil A. Zakai, MD, discusses how to treat anemia in a patient who refuses packed red blood cells. And don't forget to check out...

How to Treat Anemia in a Patient Who Refuses Transfusions for Religious Reasons

Here’s how readers responded to a You Make the Call question about a Jehovah's Witness patient with stage IV uterine cancer, a uterine abscess,...
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Mapping Silent Cerebral Infarcts in Children With Sickle Cell Anemia

Children with sickle cell anemia (SCA) are at risk of developing cerebral ischemia, including a high prevalence of silent cerebral infarcts (SCI), which can...

LentiGlobin Gene Therapy Possibly Safe for Severe Sickle Cell Disease

Interim data from a phase I study of LentiGlobin BB305 in patients with severe sickle cell disease (SCD) suggest that the gene therapy was...

Breakthroughs in Gene Therapy for Hemophilia

Gene therapy for hemophilia is here – and it’s working. The field is advancing at a steady clip: Results from recent trials of this...
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