June 2021 Volume 7 Issue 7

June 2021

Volume 7, Issue 7

This issue reviews the management and prevention of peripheral neuropathy, early successes of SCD screening programs in sub-Saharan Africa, and more.

Table of Contents

June 2021 Issue

You Make the Call

Reader Responses: How would you treat this 38-year-old patient with sickle cell trait and end-stage...

Tuesday, June 1st, 2021
Here’s how readers responded to a You Make the Call question about treatment for a patient with sickle cell trait and end-stage renal disease. Disclaimer:...

Editor’s Corner: It Takes a Village

Tuesday, June 1st, 2021
 “How do you do it all?” This is a question I have been asked often. It is a good question: I work full time, have...

Trials and Tribulations

Tuesday, June 1st, 2021
Clinical inquiry is the backbone of drug development and expansion of therapeutic options. The conduct of clinical trials is an arduous process requiring a...

June 2021 Issue

Umbralisib Demonstrates Long-Term Safety and Clinical Activity in Relapsed/Refractory Indolent Non-Hodgkin Lymphoma

Tuesday, June 1st, 2021
Patients with relapsed or refractory indolent non-Hodgkin lymphoma (iNHL) have historically had poor long-term tolerance to phosphatidylinositol-3-kinase (PI3K) inhibitors. However, new study results published...

Does Rheumatic Disease Increase Risk of MGUS Progression to Hematologic Malignancies?

Tuesday, June 1st, 2021
Patients with monoclonal gammopathy of undetermined significance (MGUS) and concomitant non-antibody (Ab)–mediated inflammatory rheumatic diseases are at increased risk of progression to overt multiple...

More COVID-19 Complications Seen in Black Patients With Sickle Cell Disease and Sickle Cell...

Tuesday, June 1st, 2021
Patients with sickle cell disease (SCD) and sickle cell trait (SCT) have significantly higher rates of hospitalization, pneumonia, and pain related to COVID-19 compared...
ASH Directions

ASH Minority Recruitment Initiative Seeks Mentors, ASH Joins in Support of the Federal Safe...

Tuesday, June 1st, 2021
Mentors Needed for ASH Minority Recruitment Initiative The American Society of Hematology (ASH) Minority Recruitment Initiative (MRI), which was created nearly two decades ago to...
The Society Pages

Remembering Thomas Brock, Xavier Becerra Confirmed as U.S. Health Secretary, and more

Tuesday, June 1st, 2021
Remembering Thomas Brock (1926 - 2021) Thomas Brock, PhD, died on April 4, 2021 at the age of 94. Dr. Brock’s discovery of a species...
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Evaluating Ibrutinib in Patients With Heavily Pretreated Hairy Cell Leukemia

Tuesday, June 1st, 2021
Treatment with ibrutinib offered durable disease control in patients with heavily pretreated classic and variant relapsed hairy cell leukemia (HCL) who were not expected...
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Older Patients With Myeloma May Have Suboptimal Response to COVID-19 Vaccination

Tuesday, June 1st, 2021
According to a study published in Blood, older patients with multiple myeloma (MM) experienced reduced efficacy with BNT162b2, Pfizer/BioNTech’s COVID-19 vaccine. However, certain factors...
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International Prognostic Tool Predicts Outcomes in Angioimmunoblastic T-Cell Lymphoma

Tuesday, June 1st, 2021
Researchers have created a novel prognostic score to predict outcomes in patients with angioimmunoblastic T-cell lymphoma (AITL), stratifying them into low-, intermediate-, and high-risk...

Rivaroxaban Reduces Risk of Cardiovascular Events in Patients With Atrial Fibrillation on Hemodialysis

Tuesday, June 1st, 2021
Compared with vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs) are associated with a superior risk-benefit profile in patients with normal renal function or...

Comparing Real-World Versus Clinical Trial Outcomes for Acute Promyelocytic Leukemia

Tuesday, June 1st, 2021
A recent study published in Leukemia & Lymphoma examined one-month mortality and overall survival (OS) data of patients diagnosed with acute promyelocytic leukemia (APL)...

Tandem High-Dose Influenza Vaccine Offers Durable Seroprotection for Patients With Plasma Cell Dyscrasias

Tuesday, June 1st, 2021
Tandem high-dose influenza vaccination may result in more durable serologic immunity in patients with plasma cell dyscrasias (PCDs), compared with standard vaccination, according to...

Will the FDA Crack Down on Clinical Trial Reporting Noncompliance?

Tuesday, June 1st, 2021
The FDA has issued its first notice of noncompliance to Acceleron Pharma for failing to submit clinical trial results to ClinicalTrials.gov, the federal government’s...

Medicare Sequestration Delay Extended Through 2021

Tuesday, June 1st, 2021
Following Senate approval, the U.S. House of Representatives voted 384-38 in favor of continuing to delay the return of Medicare sequestration through December 31....
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Acalabrutinib Induces Durable Remission in Patients With Treatment Naïve Chronic Lymphocytic Leukemia

Tuesday, June 1st, 2021
Treatment with the next-generation covalent Bruton tyrosine kinase (BTK) inhibitor acalabrutinib was safe and led to durable, long-term remission in a small group of...

Beam Therapeutics Develops Inlaid Base Editing Technique for SCD

Tuesday, June 1st, 2021
Beam Therapeutics is testing a new form of CRISPR-based technology called inlaid base editing to modify cells from patients with sickle cell disease (SCD). Base...

Can Caloric Restriction Improve Chemotherapy Response in Overweight Patients With ALL?

Tuesday, June 1st, 2021
Previous reports have found that patients who are overweight or obese during B-cell acute lymphocytic leukemia (B-ALL) induction therapy are at a higher risk...

June 2021 Issue

Pulling Back the Curtain: Claire McLintock, MD

Tuesday, June 1st, 2021
In this edition, Claire McLintock, MD, discusses her work at the intersection of women’s health and hematology and her experience as president of the...

Pain Pointers

Tuesday, June 1st, 2021
Early intervention and careful management are critical in the treatment of peripheral neuropathy Peripheral neuropathy is a common occurrence in patients with hematologic diseases, whether...

Improving Sickle Cell Disease Outcomes in Sub-Saharan Africa Starts With Screening

Tuesday, June 1st, 2021
For patients with sickle cell disease (SCD) living in sub-Saharan Africa, early intervention drastically improves long-term health outcomes, but challenges around funding, training, and...

June 2021 Issue

How I Treat In Brief

Venetoclax-Based Treatments for Chronic Lymphocytic Leukemia

Tuesday, June 1st, 2021
William G. Wierda, MD, PhD, and Francesco Paolo Tambaro, MD, PhD, review the role of venetoclax and other targeted therapies in the treatment of...
You Make the Call

You Make the Call: How would you treat this 38-year-old patient with sickle cell trait...

Tuesday, June 1st, 2021
This month, Maureen Achebe, MD, MPH, discusses treatment for a patient with sickle cell trait and end-stage renal disease. And don't forget to check out...