Focus on Classical Hematology (Volume 4, Issue 12.1)

October 2018 Special Edition

Volume 4, Issue 12.1

In this special edition, we take a look at the latest updates in classical hematology, from advances in gene therapy for hemophilia to a debate about intravenous iron in pregnant women with iron-deficiency anemia, and more.

Table of Contents

October 2018 Special Edition

Tumor Site, D-Dimer Markers Predict VTE Risk in Patients With Cancer

Friday, September 28th, 2018
Venous thromboembolism (VTE) is a common complication of cancer, with the risk of developing VTE varying greatly depending on several patient and disease factors....

Gene Therapy Alleviates Transfusion Burden in Patients With Beta-Thalassemia

Friday, September 28th, 2018
Treatment with gene therapy reduced or eliminated the need for long-term red blood–cell (RBC) transfusions in some patients with severe, transfusion-dependent beta-thalassemia, according to...

October 2018 Special Edition

LentiGlobin Gene Therapy Possibly Safe for Severe Sickle Cell Disease

Friday, September 28th, 2018
Interim data from a phase I study of LentiGlobin BB305 in patients with severe sickle cell disease (SCD) suggest that the gene therapy was...

Researchers Define Long-Term Outcomes of Cancer-Associated Thrombosis

Friday, September 28th, 2018
Patients diagnosed with cancer-associated thrombosis (CAT) remain at a high risk for recurrent venous thromboembolism (VTE), bleeding, and death – even while on therapeutic...

Romiplostim Helps Patients With Glioblastoma and Thrombocytopenia Stay on Treatment

Friday, September 28th, 2018
Temozolomide (TMZ) is part of the standard treatment for patients with glioblastoma, but the drug carries a dosedependent risk of grade 3 or 4...

How Do Patient and Physician Attitudes Drive Choices in Antiplatelet Therapy for Thrombocytopenia?

Friday, September 28th, 2018
Patients with a hematologic malignancy and thrombocytopenia typically are treated with antiplatelet drugs, but there is little information to help clinicians balance the potential...

October 2018 Special Edition

Breakthroughs in Gene Therapy for Hemophilia

Friday, September 28th, 2018
Gene therapy for hemophilia is here – and it’s working. The field is advancing at a steady clip: Results from recent trials of this...

How Should We Treat Pregnant Women With Iron Deficiency?

Friday, September 28th, 2018
Iron deficiency is prevalent among pregnant women, as maternal iron is used to supply the needs of the fetus and placenta, and additional iron...

How I Teach the Coagulation Cascade

Friday, September 28th, 2018
In this issue, Alice Ma, MD, shares her advice for teaching the coagulation cascade – to hematologists and non-hematologists, medical students, and attendings. Why is...

October 2018 Special Edition

American Society of Hematology’s Guidelines for Venous Thromboembolism and von Willebrand Disease

Friday, September 28th, 2018
In 2018, the American Society of Hematology (ASH) has continued its efforts to develop and publish evidence-based clinical practice guidelines to help practicing hematologists...

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