December 2020, Volume 6, Issue 15

December 2020

Volume 6, Issue 15

This issue explores non-clinical career opportunities for doctors, hematologic concerns for transgender patients, and more.

Table of Contents

December 2020 Issue

A Loyalty to Truth and Science

Tuesday, December 1st, 2020
Last year, the American Society of Hematology (ASH) selected Zachary Kiser, PhD, as its 2019-2020 ASH Congressional Fellow. The Congressional Fellow program aims to...

Supporting Self Education

Tuesday, December 1st, 2020
Here, Jayshree Shah, AOCNP, RN, FNP-C, MSN, describes the importance of self-education and how her role as a nurse educator has changed during the...
You Make the Call

Reader Responses: Can I start cytoreductive therapy in a patient with low-risk polycythemia vera?

Tuesday, December 1st, 2020
Here’s how readers responded to a You Make the Call question about cytoreductive therapy in a patient with low-risk polycythemia vera. Disclaimer: ASH does not...

A Day in the Life: A Man on a Mission

Tuesday, December 1st, 2020
In this edition, Pierre Noel, MD, walks us through a typical day in the atypical life of a hematologist and military medicine specialist.Institution: Mayo Clinic,...

Editor’s Corner: Running on Empty

Tuesday, December 1st, 2020
When I was a boy growing up in New Jersey and Virginia, every year our nuclear family piled into an olive 1974 Dodge Dart...
You Make the Call

Reader Responses: How would you treat this patient with JAK2-positive essential thrombocythemia?

Tuesday, December 1st, 2020
Here’s how readers responded to a You Make the Call question about anticoagulation in a patient with essential thrombocythemia. Disclaimer: ASH does not recommend or...

December 2020 Issue

Report Finds CRISPR Gene Editing Leads to Unintended Changes in Human Embryos

Tuesday, December 1st, 2020
While using CRISPR gene editing technology to repair a gene in human embryos that causes hereditary blindness, scientists at Columbia University found additional unintended...

Investigation Suggests HHS Is Concealing COVID-19 Hospitalization Data

Tuesday, December 1st, 2020
The U.S. government has been gathering data on which hospitals in which communities are reaching capacity amid the coronavirus pandemic – without sharing this...

Cybercriminals Target U.S. Hospitals as Coronavirus Cases Increase

Tuesday, December 1st, 2020
The Federal Bureau of Investigation, the Department of Health and Human Services (HHS), and the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency...

CSL889 Receives Orphan Drug Designation for SCD

Tuesday, December 1st, 2020
The FDA and the European Commission have granted orphan drug designation to CSL889, a plasma-derived hemopexin therapy, for the treatment of sickle cell disease...

CDC Says Health Care Workers Will Receive First Doses of Coronavirus Vaccine

Tuesday, December 1st, 2020
According to José Romero, MD, Chair of the Centers for Disease Control’s (CDC’s) Advisory Committee on Immunization Practices (ACIP), health care workers will receive...

Normal Results on D-Dimer Testing Can Safely Rule out Deep Vein Thrombosis

Tuesday, December 1st, 2020
A simplified approach of an initial stand-alone D-dimer test followed by a single whole-leg compression ultrasound (CUS) in D-dimer positive patients can effectively and...
ASH Directions

Highlights of ASH® Goes Virtual, Trainee Awards for Underrepresented Minorities, and more

Tuesday, December 1st, 2020
Highlights of ASH® Goes Virtual Each year, the American Society of Hematology’s (ASH’s) Highlights of ASH® meeting series offers a synopsis of the top hematology...

Female Underrepresentation Persists Among Patients Enrolled in Hematologic, Solid Tumor Trials

Tuesday, December 1st, 2020
While clinical trials have increasingly included female participants over the past 40 years, women are underrepresented in clinical trials of cancer treatments compared with...

Optimizing Outcomes With Azacitidine Treatment in Patients With MDS

Tuesday, December 1st, 2020
Delays in treatment with azacitidine predicted lower survival rates in patients with myelodysplastic syndromes (MDS), independently of the International Prognostic Scoring System (IPSS) score...

Fostamatinib More Effective Earlier in Treatment for Immune Thrombocytopenia

Tuesday, December 1st, 2020
Fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, was more effective and had similar safety when used as a second-line therapy, rather than as a...

Ixazomib Maintenance Delays Progression in Non-Transplanted Patients With Newly Diagnosed Myeloma

Tuesday, December 1st, 2020
Postinduction maintenance therapy with the oral proteasome inhibitor ixazomib prolonged progression-free survival (PFS) in patients with newly diagnosed multiple myeloma (MM) who were not...

Treatment With Caplacizumab Allows Patients to Delay or Omit Plasma Exchanges

Tuesday, December 1st, 2020
Treatment of acquired thrombotic thrombocytopenic purpura (aTTP) with caplacizumab, but without plasma exchange, increased platelet counts and improved surrogate parameters of organ damage in...
The Society Pages

NIH Award Supports Sickle Cell Disease Treatment in Malawi, NCI Outstanding Investigator Awards Granted...

Tuesday, December 1st, 2020
Saad Usmani Receives 2020 Multiple Myeloma Excellence Award from International Congress on Controversies in MM The International Congress on Controversies in Multiple Myeloma (COMy) has...
WIB_icon

Adding Dexamethasone to Isatuximab Improves Responses, Progression-Free Survival in Myeloma

Tuesday, December 1st, 2020
The combination of dexamethasone with isatuximab was associated with increased responses and improvements in survival compared with isatuximab monotherapy in patients with relapsed/refractory multiple...
WIB_icon

Tandem CD19/CD20 CAR T Cells Produce Durable Antitumor Response in Relapsed/Refractory Non-Hodgkin Lymphoma

Tuesday, December 1st, 2020
Infusions of tandem CD19- and CD20-targeting chimeric antigen receptor (CAR) T cells (TanCAR7) led to potent and durable antitumor responses in patients with relapsed/refractory...
WIB_icon

SARS-CoV-2 Antibodies Decline Over Time in COVID-19 Convalescent Plasma

Tuesday, December 1st, 2020
Antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, appear to decline over time in donated convalescent plasma, according...
WIB_icon

Targeting Higher Factor VIII Troughs Reduced Bleed Rates in Patients With Severe Hemophilia A

Tuesday, December 1st, 2020
Targeting factor VIII (FVIII) trough levels of 1 to 3% and 8 to 12% with rurioctocog alfa pegol effectively reduced bleeding rates in patients...

NK Cell Therapy Receives Orphan Drug Designation for Multiple Myeloma

Tuesday, December 1st, 2020
The FDA has granted orphan drug designation to XNK Therapeutics’ autologous cell therapy CellProtect for the treatment of multiple myeloma (MM). CellProtect is produced...
WIB_icon

Immune Checkpoint Inhibitors May Increase Thromboembolism Risk

Tuesday, December 1st, 2020
Patients with cancer who are treated with immune checkpoint inhibitors are at an increased risk of developing venous thromboembolism (VTE) and arterial thromboembolism (ATE),...
WIB_icon

Lower Socioeconomic Status Associated With Worse Post-Transplant Survival in Children With Cancer

Tuesday, December 1st, 2020
According to an analysis of data from the Center for International Blood and Marrow Transplant Research (CIBMTR), children with cancer who have Medicaid insurance...

Pediatric-Inspired Pegaspargase Regimen Shows Promise for Treatment of ALL/LBL

Tuesday, December 1st, 2020
A pediatric-inspired treatment regimen incorporating pegaspargase timed to avoid overlapping toxicities was associated with manageable toxicity, high measurable residual disease (MRD) negativity rates, and...

Mogamulizumab Demonstrates Antitumor Activity in Adult T-Cell Leukemia/Lymphoma

Tuesday, December 1st, 2020
Nearly two-thirds of patients with adult T-cell leukemia-lymphoma (ATLL) responded to treatment with mogamulizumab as a single agent or as part of a treatment...

FDA Advisory Committee Debates Coronavirus Vaccine Guidelines

Tuesday, December 1st, 2020
In a virtual meeting on October 22, a panel of academic experts in immunology, infectious diseases, and biostatistics debated the FDA’s guidelines for quickly...

Drugmakers and Health Authorities Prepare For Potential Theft of Future Vaccines

Tuesday, December 1st, 2020
Pharmaceutical companies, health authorities, hospitals, and other links in the health care supply chain are preparing to ramp up anti-theft efforts in the storage,...

December 2020 Issue

Leaving the Bedside

Tuesday, December 1st, 2020
Career opportunities for doctors extend far beyond the patient care setting. When choosing to become a physician, most people expect to spend their entire working...

Investing in the Future: An Interview With Judith Gasson, PhD

Tuesday, December 1st, 2020
Judith Gasson, PhD, the 2020 ASH Mentor Award recipient for basic science, shares her three simple rules for running a lab and her thoughts...

What Is the Optimal Treatment of ITP?

Tuesday, December 1st, 2020
In recent years, the number of treatment options available for patients with immune thrombocytopenia (ITP) has expanded. In addition to the classical trio of...

Lift Every Voice: Tamara Dunn, MD

Tuesday, December 1st, 2020
In this edition, Tamara Dunn, MD, sings the praises of singing. Dr. Dunn has been using her voice to bring smiles to patients’ faces...

What Makes a Good Leader?

Tuesday, December 1st, 2020
Health care leadership roles are often awarded to top clinicians and researchers, but experts say successful leaders need a different set of skills.  As cases...

Pulling Back the Curtain: Elli Papaemmanuil, PhD

Tuesday, December 1st, 2020
In this edition, Elli Papaemmanuil, PhD, talks about the varied childhood experiences that resulted from her father’s Greek military service, and how the Human...

Opportunity, Not Obligation: An Interview With Wendy Stock, MD

Tuesday, December 1st, 2020
Wendy Stock, MD, the 2020 ASH Mentor Award recipient for clinical medicine, speaks about the joy of cultivating the next generation of clinicians and...

Hematology and the Transgender Patient

Tuesday, December 1st, 2020
An estimated 1.4 million U.S. adults (0.6% of all adults) self-report as transgender; yet, to date, little research has been conducted to understand cancer...

December 2020 Issue

How I Treat In Brief

Safe Pain Management With Opioid Therapy

Tuesday, December 1st, 2020
This month, Holly L. Geyer, MD; Halena Gazelka, MD; and Ruben Mesa, MD, provide a case-based discussion of how to manage pain safely with...

Hematology In-Service Exam: Adapting for COVID-19 and Beyond

Tuesday, December 1st, 2020
The American Society of Hematology’s (ASH’s) Hematology In-Service Exam (ISE) is a low-stakes exam that has been offered to hematology fellows since 2009. The...
You Make the Call

You Make the Call: How would you treat this patient with JAK2-positive essential thrombocythemia?

Tuesday, December 1st, 2020
This month, Ruben Mesa, MD, discusses anticoagulation in a patient with essential thrombocythemia. And don't forget to check out next month's clinical dilemma - send...
You Make the Call

You Make the Call: Can I start cytoreductive therapy in a patient with low-risk...

Tuesday, December 1st, 2020
This month, Ayalew Tefferi, MD, discusses cytoreductive therapy in a patient with low-risk polycythemia vera. And don't forget to check out next month's clinical dilemma...

Systems-Based Hematology Success Stories

Tuesday, December 1st, 2020
Investment Will Bolster Growing Subspecialty Five years ago, the American Society of Hematology (ASH) introduced the concept of a new subspecialty called the systems-based hematologist.1...
How I Treat In Brief

How I Treat Cancer-Associated Anemia

Tuesday, December 1st, 2020
This month, Jeffrey A. Gilreath, PharmD, and George M. Rodgers, MD, PhD, review common and complex scenarios in the management of anemic patients with cancer. This...

Demystifying DNA Variant Reporting

Tuesday, December 1st, 2020
As the understanding of the pathogenesis of hematologic malignancies advances, molecular profiling by next-generation sequencing (NGS) is playing larger role in the diagnosis, prognosis,...