April 2017, Volume 3, Issue 5

April 2017

Volume 3, Issue 5

This issue examines the art and science of myeloma drug sequencing, Mikkael Sekeres’ letter to the ABIM, highlights from the 16th International Myeloma Workshop, and more.

Table of Contents

April 2017

Letter From a Cleveland Jail to the ABIM: Patient Practicum

Tuesday, March 28th, 2017
Dear American Board of Internal Medicine (ABIM): Writing to you, as usual, from behind the bars of emotional turmoil, political dissonance, and unresolved neuroses regarding...

April 2017

Fred Hutch Launches APOLLO Network for the Cancer Moonshot Initiative, University of Arizona to...

Tuesday, March 28th, 2017
Fred Hutchinson Researchers to Assess Protein Assays for the Cancer Moonshot Initiative As part of the Cancer Moonshot initiative, the APOLLO (Applied Proteogenomics Organizational Learning...

The ASH Bridge Grant Program, Announcing the 2017 TRTH Program Participants, and more

Tuesday, March 28th, 2017
Apply for the ASH Bridge Grant Program ASH is accepting applications for the Bridge Grant Program through May 1, 2017. The program was created to...

April 2017

Order Matters: The Art and Science of Myeloma Drug Sequencing

Tuesday, March 28th, 2017
Examining the who, what, when, where, and why of myeloma treatment In 1844, Thomas Alexander Bean, one of the first documented patients with multiple myeloma...

April 2017

What are the prescribing options in the case of anticoagulation failure in deep vein...

Tuesday, March 28th, 2017
This month, Joel S. Bennett, MD, discusses the possibility of novel oral anticoagulant failure in a patient with deep vein thrombosis. And don't forget to...

Research by Design

Tuesday, March 28th, 2017
Educating young scientists to design successful research projects often comes down to teaching them the right questions to ask. A high-quality educational research project begins...

April 2017

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Targeted Chemotherapy Improves Renal Outcomes in Patients With Plasma Cell Dyscrasias and C3 Glomerulopathy

Tuesday, March 28th, 2017
Patients with monoclonal gammopathies often face a spectrum of renal manifestations, including C3 glomerulopathy (C3G), which may be attributable to the presence of the...

FDA Revisits Off-Label Communication in Draft Guidance for Medical Product Labeling

Tuesday, March 28th, 2017
In response to requests from drug manufacturers that they be able to communicate supplementary data and information about a product’s “off-label” uses in promotional...

Start-Up Plans to Raise $1 Billion to Develop Liquid Biopsy to Detect Cancer

Tuesday, March 28th, 2017
The biotechnology start-up Grail recently announced its plan to raise $1 billion in financing to create a liquid biopsy assay that could detect cancer...

FDA Grants Priority Review for Inotuzumab Ozogamicin for ALL

Tuesday, March 28th, 2017
The FDA granted priority review for inotuzumab ozogamicin, an anti-CD22 monoclonal antibody, for the treatment of adult patients with relapsed/refractory B-cell precursor acute lymphocytic...

Report Finds Americans are Seeking Medications Abroad for Cheaper Prices

Tuesday, March 28th, 2017
When purchased outside the country, many prescription medicines cost less than half of what they do in the United States, driving more Americans to...

Identifying Genetic Mutations That Can Predict Transplant Outcome in Patients With Myelodysplastic Syndromes

Tuesday, March 28th, 2017
Though allogeneic hematopoietic cell transplantation (alloHCT) is the only curative option for myelodysplastic syndromes (MDS), transplant-related mortality, complication rates, and available, suitable donors preclude...

Efficacy of Eltrombopag in Patients With Lower-Risk Myelodysplastic Syndromes and Thrombocytopenia

Tuesday, March 28th, 2017
Platelet transfusions are commonly administered to patients with myelodysplastic syndromes (MDS) who develop profound thrombocytopenia, but the short therapeutic effect and eventual transfusion refractoriness...

POT-KAST and POT-CAST: Questioning Routine Thromboprophylaxis After Casting or Knee Surgery

Tuesday, March 28th, 2017
The value of prescribing thromboprophylaxis to prevent venous thromboembolism (VTE) after knee arthroscopy or casting of the lower leg is debatable, and the risk−benefit...
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Can Pomalidomide Plus Dexamethasone “Rescue” Patients With Relapsed/ Refractory Amyloid Light-Chain Amyloidosis?

Tuesday, March 28th, 2017
Patients with amyloid light-chain (AL) amyloidosis are often treated upfront with combinations of alkylating agents and bortezomib; when they don’t respond to this regimen...
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Encouraging Trends in Six-Month Mortality in Amyloid Light-Chain Amyloidosis

Tuesday, March 28th, 2017
With recent advances in diagnosis, treatment, and response assessment, clinicians have observed a significant decrease in six-month mortality (p<0.001) among patients with amyloid light-chain...
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Can Podoplanin Explain the Connection Between Brain Tumors and Venous Thromboembolism?

Tuesday, March 28th, 2017
Podoplanin, a sialomucin-like glycoprotein that can induce blood platelet activation, is frequently expressed by primary brain tumors. Its overexpression can contribute to a greater...

Third Patient Death Reported in SL-401 Drug Trial for Patients With BPDCN and AML

Tuesday, March 28th, 2017
The manufacturers of SL-401, a targeted therapy directed at the interleukin-3 receptor CD123, reported a third patient death in the ongoing phase II trial...

April 2017

A Tale of Two Proteasome Inhibitors: Carfilzomib Versus Bortezomib in Multiple Myeloma

Tuesday, March 28th, 2017
At the 16th International Myeloma Workshop (IMW), two clinical trials of patients with newly diagnosed and relapsed/refractory multiple myeloma (NDMM; RRMM) showed disparate results....

Denosumab Delays Skeletal-Related Events in Newly Diagnosed Multiple Myeloma

Tuesday, March 28th, 2017
Denosumab (a monoclonal antibody that targets the RANK ligand) was noninferior to zoledronic acid (ZA) in delaying the time to a first skeletal-related event...

The Multiple Myeloma Genome Project: Developing a Risk Stratification System for Multiple Myeloma

Tuesday, March 28th, 2017
An update from the Multiple Myeloma Genome Project (MMGP), presented at the 16th International Myeloma Workshop (IMW), revealed several associations between the development of...

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