Gene Therapy: The Comeback Kid of Hematology Treatments?
Despite slow progress and unexpected setbacks, the future of gene therapy remains bright.
Ashanthi de Silva was the first human to be treated successfully with gene therapy. At the time, in 1990, she was a...
Online Exclusives
FDA Committee Votes to Withdraw Two Accelerated Approvals of Cancer Treatments
The U.S. Food and Drug Administration’s (FDA’s) Oncologic Drugs Advisory Committee (ODAC) recommended withdrawing two of six accelerated approvals of cancer treatments that it...
Pipette Tip Shortage Hinders Scientific Work Worldwide
An ongoing pipette tip shortage caused by the COVID-19 pandemic, blackouts in Texas, and a manufacturing plant fire is hindering scientific work around the...
News
From the Blood Journals
Reduced Calf Muscle Pump Function Predicts VTE and Mortality Risk
Reduced calf pump function (CPF) appears to be a risk factor for venous thromboembolism (VTE), according to a study published in Blood. In addition,...
Adding Brentuximab Vedotin to Chemotherapy Improves Outcomes in Pediatric ALK-Positive ALCL
The addition of brentuximab vedotin to chemotherapy led to favorable overall survival (OS) and event-free survival (EFS) in children with ALK-positive anaplastic large cell...
Multimedia
Deepu Madduri: Ciltacabtagene Autoleucel in Relapsed/Refractory Multiple Myeloma
Deepu Madduri, MD, discusses data from the phase Ib/II CARTITUDE-1 study evaluating chimeric antigen receptor (CAR) T cell therapy ciltacabtagene autoleucel in patients with...
Steven Pipe: Etranacogene Dezaparvovec Gene Therapy for Hemophilia B
Steven Pipe, MD, shares safety and efficacy data from a phase III study of etranacogene dezaparvovec gene therapy in patients with hemophilia B.
Charlotte Bradbury: Adding Mycophenolate to Corticosteroid for ITP
Mycophenolate alongside corticosteroids may be considered as an effective first-line treatment option for some patients with immune thrombocytopenia. Charlotte Bradbury, MD, discusses results from...
José Blanco: Accessory Splenectomy in Patients with Immune Cytopenias
José Blanco, MD, discusses whether searching for an accessory spleen or performing accessory splenectomy is a safe and effective treatment for patients with refractory...
On Location
PATHFINDER: Avapritinib Induces Rapid Responses in Advanced Systemic Mastocytosis
Three-quarters of patients with advanced systemic mastocytosis (SM) responded to treatment with the oral KIT...
Evaluating a New Bispecific CAR T-Cell Therapy for B-Cell Lymphomas
In a first-in-human phase I clinical trial of a bispecific anti-CD19/CD20 chimeric antigen receptor (CAR)...
Copanlisib Plus Rituximab Improves Progression-Free Survival in Indolent Non-Hodgkin Lymphoma
Combining copanlisib with rituximab reduced the risk of progression or death by 48%, compared with...
Researchers Recommend New Processes for Bone Marrow Screening for HLH
For patients suspected of having hemophagocytic lymphohistiocytosis (HLH), bone marrow biopsy is often used to...
e-IRON: Iron-Deficiency Anemia Management at Warp Speed
A telemedicine pilot program to triage and expedite the management of patients with iron-deficiency anemia...
TPO-RAs and ITP: Eltrombopag Induces High Efficacy, But Avatrombopag Offers Advantages
A pair of studies presented at the 2020 American Society of Hematology Annual Meeting analyzed...
Latest Headlines
ASH Directions
ASH Presents FAQ Resource for Thrombosis with Thrombocytopenia, ASH News Daily Seeks 2021 Authors,...
New COVID-19 Resource: FAQ About Thrombosis with Thrombocytopenia Syndrome
The American Society of Hematology (ASH) has released a resource to guide clinicians in recognizing and...
ASH Announces First Round of Research Restart Awardees, 2020 ASH Annual Report Now Available,...
ASH Announces First Round of Research Restart Awardees
The American Society of Hematology (ASH) has announced the names of 19 early-career investigators who will receive critical...
Senate Confirms Surgeon General and Assistant Secretary for Health, HVO Presents Golden Apple Awards,...
Brian Bolwell Named Chair of Physician Leadership and Development at Cleveland Clinic
The Cleveland Clinic has appointed Brian Bolwell, MD, FACP, as chair of physician...
Remembering Emil Freireich, Millie Hughes-Fulford, and more
Remembering Emil Freireich (1927 – 2021)
Renowned hematologist and researcher Emil Freireich, MD, died on February 1, 2021, at the age of 93.Dr. Freireich had...
Remembering Art Nienhuis, Thomas Edgington, and more
Remembering Art Nienhuis (1941 – 2021)
Gene therapy pioneer Art Nienhuis, MD, passed away on February 3, 2021, at the age of 79.Dr. Nienhuis was...
Gene Therapy: The Comeback Kid of Hematology Treatments?
Despite slow progress and unexpected setbacks, the future of gene therapy remains bright.
Ashanthi de Silva was the first human to be treated successfully with...
Four of a Kind?
Soon, there may be as many as four JAK inhibitors available for patients with myelofibrosis.
For many of his patients with myelofibrosis, ruxolitinib has been...
Cellular Therapies Hold Promise in Myeloid Malignancies
There is hope that these therapies will improve outcomes, but development is still in early stages.
A recent spate of approvals of targeted treatments, such...