The Geography of Drug Approvals

How can regulators look at the same data and get different results? The goal of regulatory bodies such as the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the African Medicines...

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FDA Announces New Plans to Regulate Tobacco and Nicotine Products

The U.S. Food and Drug Administration (FDA) has announced a multi-year, comprehensive plan for tobacco and nicotine regulation that aims to reduce tobacco-related disease...

FDA Approves Ibrutinib as First Therapy for Chronic-Graft-Versus Host Disease

The U.S. Food and Drug Administration (FDA) approved ibrutinib – a Bruton tyrosine kinase inhibitor that treats mantle cell lymphoma, chronic lymphocytic leukemia, and...

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From the Blood Journals

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Number of Older Patients Receiving AlloHCT Increased Over the Past Decade

Historically, older adults have not been considered optimal candidates for hematopoietic cell transplantation (HCT) because of concerns about transplant-related toxicity and mortality. Over the...
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Examining Nilotinib to Prevent Post-Transplant Relapse in Patients With Ph+ Leukemia

In previous research published in Blood, Paul A. Carpenter, MBBS, from the Fred Hutchinson Cancer Research Center in Seattle, Washington, and co-authors determined that...

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Eytan M. Stein, MD: Enasidenib Shows “Encouraging” Efficacy in IDH2-Mutated AML

Treatment with the IDH2 inhibitor enasidenib was well-tolerated and led to an "impressive" response rate in patients with relapsed/refractory IDH2-mutated acute myeloid leukemia. Dr....
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Jae Hong Park, MD: Improving Outcomes, Minimizing Toxicity With CAR T-Cell...

Dr. Park reviews two studies identifying characteristics that can improve durability of outcome, without increasing toxicity, in patients with B-cell acute lymphocytic leukemia.
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Frederick Locke, MD: CAR T-Cell Therapy in Relapsed/Refractory NHL

Based on results of the ZUMA-1 trial, axicabtagene ciloleucel was submitted to the FDA earlier this year for patients with chemotherapy-refractory, aggressive non-Hodgkin lymphomas....
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Mathias Rummel, MD, PhD: Bendamustine-Rituximab “StiL” Beats R-CHOP for Indolent Lymphomas

Ten-year results from the randomized, phase III StiL trial show that bendamustine plus rituximab leads to longer progression-free survival than R-CHOP in patients with...

On Location

Is Anticoagulant Therapy to Prevent Recurrent VTE Worth the Bleeding Risk in Older Patients With Cancer?

Though anticoagulants are common frontline treatment for patients with venous thromboembolism (VTE), patients with cancer...

Phase II Results Show Activity of Polatuzumab Vedotin Combination in DLBCL

The CD79b-targeting antibody drug conjugate polatuzumab vedotin, in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone...

Evaluating HCT Outcomes in Patients With Beta-Thalassemia

Hematopoietic cell transplantation (HCT) is associated with a disease-free survival rate of 90 percent at...

Fourth Drug’s the Charm? Comparing Combination Therapies in the Myeloma XI Trial

Triplet combinations of anti-myeloma induction therapies lead to deeper, longer remissions than doublet combinations. Results...

Ropeginterferon Alfa-2B Versus Hydroxyurea in Patients With Polycythemia Vera

Treatment with ropeginterferon alfa-2B, a mono-pegylated proline interferon, reduced JAK2 allele burden in patients with...

Fostamatinib Improves Platelet Counts in Certain Patients With Heavily Pretreated ITP

In a phase II study published in Blood, the oral SYK inhibitor fostamatinib was safe...

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ASH Directions

ASH Selects Outstanding Trainees for Award Programs, Honorific Award Winners, and more

ASH Selects Outstanding Trainees for Award Programs 2017 ASH Research Training Award for Fellows ASH selected 11 fellows for the 2017 ASH Research Training Award for...

ASH Co-Hosts Congressional Briefing on Sickle Cell Disease, Blood Journal’s Impact On the Rise,...

ASH Co-Hosts Congressional Briefing on Sickle Cell DiseaseThe American Society of Hematology (ASH) co-hosted a congressional briefing on sickle cell disease (SCD) and gene...

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Ned Sharpless Named New NCI Director, 2017 Pew-Stewart Cancer Research Scholars Announced, and more

Norman Sharpless Named Director of the National Cancer Institute Norman “Ned” Sharpless, MD, has been appointed director of the National Cancer Institute (NCI) by President...

Remembering H. Jean Khoury, NCI Funds Standardization of Cancer Genomic Data, and more

Remembering H. Jean Khoury (1967-2017) H. Jean Khoury, MD, an expert in hematologic malignancies at the Winship Cancer Institute of Emory University, died at age...

Remembering Neil Abramson, MD, AACC Announces Clinical Chemistry Trainee Council Educational Initiative, and more

Remembering Neil Abramson, MD (1937-2017) Neil Abramson, MD, a hematologist/oncologist who served as a Blood Special Section Editor from 2008-2012, passed away at the age...

The Geography of Drug Approvals

How can regulators look at the same data and get different results? The goal of regulatory bodies such as the U.S. Food and Drug Administration...

It Runs in the Blood

For these doctors, hematology is “the family business” The term “family business” may conjure images of stores, restaurants, and other commercial enterprises, but it turns...

Show Me the Money? Show Us the Data!

How will NIH’s new requirement that federally funded clinical trials report outcomes affect researchers? The merits and cautions of data sharing have long been a...