Charting the Myeloma Immunotherapy Landscape
A bevy of forthcoming immunotherapies for multiple myeloma over the next few years raises hopes, as well as questions about combinations, sequencing, and potential for a new standard of care for frontline therapy.
The approval...
Online Exclusives
FDA Accepts IND Application for PBCAR19B
The FDA cleared Precision BioSciences’ Investigational New Drug (IND) application for its chimeric antigen receptor (CAR) T-cell therapy PBCAR19B. The company will initiate a...
IND Application Cleared for VOR33 in CD33+ Acute Myeloid Leukemia
The FDA cleared Vor Biopharma’s IND application for its hematopoietic cell therapy VOR33. This decision allows the company to initiate a phase I/IIa clinical...
News
From the Blood Journals
Older Age, Pre-Existing Comorbidities Increase Poor Outcomes in Patients With SCD...
Patients with sickle cell disease (SCD) have poor outcomes associated with COVID-19, particularly if they are older or present with end organ damage, acute...
Risk of Subsequent Malignant Neoplasms Is Low in Children With Hodgkin...
A study published in Blood suggests that children and adolescents with intermediate-risk Hodgkin lymphoma have a relatively low cumulative risk of developing subsequent malignant...
Multimedia
Deepu Madduri: Ciltacabtagene Autoleucel in Relapsed/Refractory Multiple Myeloma
Deepu Madduri, MD, discusses data from the phase Ib/II CARTITUDE-1 study evaluating chimeric antigen receptor (CAR) T cell therapy ciltacabtagene autoleucel in patients with...
Steven Pipe: Etranacogene Dezaparvovec Gene Therapy for Hemophilia B
Steven Pipe, MD, shares safety and efficacy data from a phase III study of etranacogene dezaparvovec gene therapy in patients with hemophilia B.
Charlotte Bradbury: Adding Mycophenolate to Corticosteroid for ITP
Mycophenolate alongside corticosteroids may be considered as an effective first-line treatment option for some patients with immune thrombocytopenia. Charlotte Bradbury, MD, discusses results from...
José Blanco: Accessory Splenectomy in Patients with Immune Cytopenias
José Blanco, MD, discusses whether searching for an accessory spleen or performing accessory splenectomy is a safe and effective treatment for patients with refractory...
On Location
Researchers Recommend New Processes for Bone Marrow Screening for HLH
For patients suspected of having hemophagocytic lymphohistiocytosis (HLH), bone marrow biopsy is often used to...
e-IRON: Iron-Deficiency Anemia Management at Warp Speed
A telemedicine pilot program to triage and expedite the management of patients with iron-deficiency anemia...
TPO-RAs and ITP: Eltrombopag Induces High Efficacy, But Avatrombopag Offers Advantages
A pair of studies presented at the 2020 American Society of Hematology Annual Meeting analyzed...
No Difference in CNS Relapse Rate According to Prophylaxis Route
According to results from a retrospective analysis of central nervous system (CNS) prophylaxis in patients...
Researchers Validate Burkitt Lymphoma Prognostic Index
Researchers have created a prognostic index specific to Burkitt lymphoma (BL) that will allow for...
Thiotepa-Containing Conditioning Regimens Improve Survival Outcomes in Patients With PCNSL
Thiotepa-containing conditioning regimens, including thiotepa/busulfan/cyclophosphamide (TBC) and thiotepa/carmustine (TT-BCNU), were associated with favorable survival outcomes...
Latest Headlines
ASH Directions
New Clinical Practice Guidelines for VTE in Cancer, Registration for 2021 Highlights of ASH®...
Now Published: ASH Clinical Practice Guidelines on VTE in Patients with Cancer
ASH’s new clinical practice guideline on the prevention and treatment of venous thromboembolism...
New Clinical Practice Guidelines for von Willebrand Disease, Announcing the 2021 ASH Scholar Award...
Just Published: Clinical Practice Guidelines on the Diagnosis and Management of von Willebrand Disease
The American Society of Hematology (ASH) has developed clinical practice guidelines for...
Remembering Art Nienhuis, Thomas Edgington, and more
Remembering Art Nienhuis (1941 – 2021)
Gene therapy pioneer Art Nienhuis, MD, passed away on February 3, 2021, at the age of 79.Dr. Nienhuis was...
Remembering James Cook, Oncology Researchers Receive 2020 NIH Director’s New Innovator Awards, and more
Remembering James Cook (1936 – 2020)
James D. Cook, MD, an esteemed teacher and mentor, passed away in November 2020. His research focused on iron...
Remembering Mark Smith, Cancer Researchers Receive 2020 AAAS Fellow Distinction, and more
Remembering Mark Smith (1962 - 2020)
Mark P. Smith, MBChB, died suddenly on September 24, 2020, at the age of 58.Since 1995, Dr. Smith has...
Charting the Myeloma Immunotherapy Landscape
A bevy of forthcoming immunotherapies for multiple myeloma over the next few years raises hopes, as well as questions about combinations, sequencing, and potential...
Instant Access: Alarming or Empowering?
As the 21st Century Cures Act’s information blocking requirements go into effect, clinicians face the realities of increased patient access.
Years ago, to share medical...
Use of Transplant Persists as Appropriate Option in PTCLs
Backed by experience, but not randomized data, most institutions have established practices for transplant in patients with peripheral T-cell lymphomas.
No consensus exists on the...