Literature Scan

New and noteworthy research from the medial literature landscape.

  • Enoxaparin Does Not Prevent Placenta-Mediated Complications in Pregnant Women With Severe Preeclampsia Tuesday, January 17th, 2017 | January Annual Meeting Edition 2017, Volume 3, Issue 2

    Pregnant women who have severe preeclampsia (a disease characterized by impaired vascular response to placentation) before 34 weeks of pregnancy are at an increased risk for severe maternal and perinatal complications, including a higher risk of developing eclampsia during subsequent pregnancies and a lower-than-average birthweight. Though research has suggested that prophylactic doses of low-molecular-weight heparin […]

  • Randomized Trial Finds Rivaroxaban a Safer Option Than Warfarin for Patients With Atrial Fibrillation Undergoing PCI Tuesday, January 17th, 2017 | January Annual Meeting Edition 2017, Volume 3, Issue 2

    The “triple-therapy” anticoagulation regimen (consisting of a vitamin K antagonist [VKA] plus dual antiplatelet therapy [DAPT] with a P2Y12 inhibitor and aspirin) has been shown to reduce thrombotic and stroke risk in patients with atrial fibrillation (AF) undergoing percutaneous intervention (PCI) with stent placement. However, this regimen does increase bleeding risk. According to results from […]

  • Lenalidomide Shows Some Antitumor Activity in Patients With Relapsed or Recurrent Adult T-Cell Leukemia/Lymphoma Thursday, December 29th, 2016 | January 2017, Volume 3, Issue 1

    Patients with adult T-cell leukemia/lymphoma (ATLL) that is resistant to chemotherapeutic regimens have few treatment options. Following a phase I study determining the maximum-tolerated dose of lenalidomide for patients with ATLL, investigators evaluated the efficacy and safety of 25 mg/day of lenalidomide in the multicenter, single-arm, open-label, phase II ATLL-002 study, which enrolled 26 patients […]

  • Examining the Link Between Cirrhosis and Venous Thromboembolism Thursday, December 29th, 2016 | January 2017, Volume 3, Issue 1

    A meta-analysis published in Thrombosis and Haemostasis, by Pasquale Ambrosino, MD, from the Department of Clinical Medicine and Surgery at the Federico II University in Naples, Italy, and authors confirmed the association between cirrhosis and venous thromboembolism (VTE), finding that patients with cirrhosis have a 1.2-percent higher absolute risk of  VTE than patients without cirrhosis […]

  • Overly Restrictive Clinical Trial Exclusion Criteria May Block Patients From Receiving Effective Therapy Thursday, December 29th, 2016 | January 2017, Volume 3, Issue 1

    Many clinical trials exclude patients with comorbidities, active or recent malignancies, organ dysfunction, or poor performance status, meaning that clinical trials typically enroll the “Olympic athletes of patients,” according to clinical trial researchers who spoke with ASH Clinical News about clinical trials’ eligibility criteria in a recent feature article (“Who’s In and Who’s Out?”). Such […]

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